INT15991

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 8.22
Pain Relevance 9.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FPR1) signal transduction (FPR1) plasma membrane (FPR1)
signal transducer activity (FPR1)
Anatomy Link Frequency
neutrophils 9
monocytes 3
macrophages 1
granulocyte 1
poly 1
FPR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 109 99.30 Very High Very High Very High
Inflammation 491 99.18 Very High Very High Very High
analgesia 180 98.12 Very High Very High Very High
Catecholamine 12 97.94 Very High Very High Very High
opioid receptor 72 97.92 Very High Very High Very High
antagonist 136 96.64 Very High Very High Very High
Enkephalin 360 96.18 Very High Very High Very High
narcan 72 95.76 Very High Very High Very High
Opioid 603 95.56 Very High Very High Very High
agonist 156 90.56 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 528 99.18 Very High Very High Very High
Adhesions 64 99.04 Very High Very High Very High
Coagulation Disorder 1 98.68 Very High Very High Very High
Nociception 216 98.24 Very High Very High Very High
Obstructive Sleep Apnea 219 95.76 Very High Very High Very High
Hypoxia 36 93.92 High High
Inflammatory Pain 171 88.20 High High
Apoptosis 68 86.84 High High
Disease 85 85.12 High High
Hyperalgesia 54 84.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The C5a or FMLP effects were more tachyphylactic in tissues continuously exposed to cycloheximide; this phenomenon was particularly pronounced for FMLP.
Gene_expression (pronounced) of FMLP
1) Confidence 0.59 Published 1991 Journal Blood Vessels Section Abstract Doc Link 1782401 Disease Relevance 0 Pain Relevance 0.09
Natural fMLP was subsequently purified and identified in supernatants of gram negative bacteria.
Gene_expression (purified) of fMLP
2) Confidence 0.55 Published 2008 Journal Pharmazie Section Abstract Doc Link 19069235 Disease Relevance 0 Pain Relevance 0
Mycobacteria activate both TLR [21],[22] and FPR [23] that are expressed on neutrophils and monocytes/macrophages [24]–[26].
Gene_expression (expressed) of FPR in macrophages
3) Confidence 0.46 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.37 Pain Relevance 1.06
For determination of [Ca2+]i, neutrophils or FPR transfected HEK293 cells were placed on dishes coated with poly-L-lysine and then loaded with 1 or 2 µM Fura 2/AM (Molecular Probes-Invitrogen) for 30 min at 37°C as previously described [79].
Gene_expression (transfected) of FPR in poly
4) Confidence 0.46 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0 Pain Relevance 0.18
In contrast, no release of Met-enkephalin after Mycobacterium butyricum stimulation was observed in human blood monocytes following short term (7 min; Fig. 2C) or long term stimulation (up to 2 h; data not shown) although monocytes express FPR [33],[34] and TLR [35].
Gene_expression (express) of FPR in monocytes associated with enkephalin
5) Confidence 0.46 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.19 Pain Relevance 1.17
However, more relevant here since the HEK cells were negative for FPR1, is the possibility that a part, possibly small, of the effects of peptide Ac2-26 might be due to actions independent from activation of any member of the FPR family [10].
Neg (negative) Gene_expression (negative) of FPR1
6) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.08 Pain Relevance 0.04
FPR is expressed on neutrophils as well as monocytes/macrophages [34].
Gene_expression (expressed) of FPR
7) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.47 Pain Relevance 0.87
Paw pressure threshold or paw withdrawal latency were measured 5 min after fMLP injection.
Gene_expression (injection) of fMLP in paw associated with withdrawal
8) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.61 Pain Relevance 1.26
We have recently transfected human FPR and ALX (the only two receptors of the group expressed by human PMN) in HEK293 cells finding that while AnxA1 displays selectivity for binding to ALX, the shorter and more flexible peptide Ac2-26, binds to both FPR and ALX with approximately equal affinity [16].
Gene_expression (transfected) of FPR
9) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.29 Pain Relevance 0.10
Specifically, we found that mycobacteria and fMLP triggered intracellular Ca2+ mobilisation in neutrophils (Fig. 4D) and in HEK293 cells transfected with human FPR but not in Mock-transfected cells (Fig. 4B).
Gene_expression (transfected) of FPR in neutrophils
10) Confidence 0.35 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.06 Pain Relevance 0.49
In accordance with previous studies [38] FPR were expressed on human blood neutrophils (Fig. 2E).
Gene_expression (expressed) of FPR in neutrophils
11) Confidence 0.35 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.11 Pain Relevance 0.85
Tolfenamic acid inhibited LTB4 production in PMNs as well as FMLP- and LTB4-induced PMN migration (IC50 values 23 +/- 3, 39 +/- 11, and 68 +/- 13 microM, respectively), whereas flunixin inhibited these cell functions only with the highest concentration tested (100 microM).
Gene_expression (production) of FMLP in PMNs
12) Confidence 0.34 Published 1993 Journal Inflammation Section Abstract Doc Link 8406686 Disease Relevance 0.24 Pain Relevance 0.09
l of HBC buffer containing 200 nM fMLP or 8 ?
Gene_expression (containing) of fMLP
13) Confidence 0.31 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.07
Similarly, Formyl Peptidase Receptor (FPR) genes are expressed by activated neutrophils.
Gene_expression (expressed) of Formyl Peptidase Receptor in neutrophils
14) Confidence 0.25 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 0.47 Pain Relevance 0.10
Similarly, Formyl Peptidase Receptor (FPR) genes are expressed by activated neutrophils.
Gene_expression (expressed) of FPR in neutrophils
15) Confidence 0.25 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 0.46 Pain Relevance 0.10
Regulation of expression of FPR on neutrophils plays a key role in neutrophil polarization and chemotaxis.
Gene_expression (expression) of FPR in neutrophils
16) Confidence 0.22 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 0.45 Pain Relevance 0.10
Considering that the synthetic peptide FMLP, mimetic of bacterial chemotaxins, only activates PMN adhesive machinery, this stimulus was selected to evaluate the effect of the compounds tested on PMNs.
Gene_expression (synthetic) of FMLP
17) Confidence 0.19 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.69 Pain Relevance 0.03
Mycobacteria activate both TLR [21],[22] and FPR [23] that are expressed on neutrophils and monocytes/macrophages [24]–[26].
Gene_expression (expressed) of FPR in monocytes
18) Confidence 0.15 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.37 Pain Relevance 1.06
Mycobacteria activate both TLR [21],[22] and FPR [23] that are expressed on neutrophils and monocytes/macrophages [24]–[26].
Gene_expression (expressed) of FPR in neutrophils
19) Confidence 0.15 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.37 Pain Relevance 1.06
Our analysis identified key regulators of innate immunity and inflammation including the proinflammatory mediators formyl peptide receptor 1, ICAM-1 (intercellular adhesion molecule-1), thymosin ?
Gene_expression (formyl) of peptide receptor 1 associated with inflammation and adhesions
20) Confidence 0.14 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400410 Disease Relevance 0.52 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox