INT15992

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Context Info
Confidence 0.60
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.91
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C5AR1) plasma membrane (C5AR1) signal transducer activity (C5AR1)
Anatomy Link Frequency
leukocytes 1
C5AR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 12 89.40 High High
Pain 1 88.32 High High
qutenza 1 25.00 Low Low
agonist 1 25.00 Low Low
Inflammation 26 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
High-pressure Neurological Syndrome 4 98.08 Very High Very High Very High
Targeted Disruption 2 97.96 Very High Very High Very High
Stress 2 97.52 Very High Very High Very High
Pneumonia 1 96.24 Very High Very High Very High
Infection 18 95.16 Very High Very High Very High
Arthralgia 1 88.32 High High
Sprains And Strains 6 49.16 Quite Low
Hemolysis 3 26.56 Quite Low
Disease 15 20.32 Low Low
Shock 4 20.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no correlation between changes in C3a and C5a levels during compression and the diagnosis of HPNS.
Regulation (changes) of C5a associated with high-pressure neurological syndrome
1) Confidence 0.60 Published 1993 Journal Undersea Hyperb Med Section Abstract Doc Link 8286982 Disease Relevance 0.55 Pain Relevance 0.09
Two distinct peptides, C5a and f-Met-Leu-Phe (FMLP), that are chemotactic for phagocytic leukocytes affect profoundly the circulation in various in vivo systems.
Regulation (chemotactic) of C5a in leukocytes
2) Confidence 0.44 Published 1991 Journal Blood Vessels Section Abstract Doc Link 1782401 Disease Relevance 0 Pain Relevance 0
Dark areas indicate controlFig. 2Cell proliferation induced by C5a. [3H]-thymidine incorporation was measured with a liquid scintillation counter 48 h after adding the various concentrations of C5a, C5, or C3a to the HMEC-1 suspension. a C5a increased HMEC-1 proliferation in a dose-dependent manner, whereas C5 (b) and C3a (c) did not induce proliferation. d HMEC-1 was stimulated with either 10 nM C5a in the presence of various concentrations of C5a receptor antagonist W-54011 (closed column) or W-54011 alone (open column).
Regulation (concentrations) of C5a associated with antagonist
3) Confidence 0.14 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2902742 Disease Relevance 0 Pain Relevance 0.09
Also up regulation was observed for HIF-1 and C5AR by BoNTA and CT and there was good agreement with data from the microarray studies (Fig. 10).


Regulation (regulation) of C5AR
4) Confidence 0.08 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2542375 Disease Relevance 0 Pain Relevance 0
Modulation of C5a responses by S. aureus proceeds through inhibition of the C5a receptor (C5aR).
Regulation (Modulation) of C5a
5) Confidence 0.05 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.36 Pain Relevance 0

General Comments

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