INT159942

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Stat5a) signal transduction (Stat5a) nucleolus (Stat5a)
nucleus (Stat5a) DNA binding (Stat5a) cytoplasm (Stat5a)
Anatomy Link Frequency
nucleus 1
Stat5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 7 99.54 Very High Very High Very High
cytokine 57 94.68 High High
opioid receptor 2 93.20 High High
antagonist 1 69.68 Quite High
narcan 1 68.80 Quite High
Inflammation 13 63.68 Quite High
mu opioid receptor 1 25.00 Low Low
Inflammatory response 1 17.44 Low Low
imagery 6 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 37 97.64 Very High Very High Very High
Stress 1 84.60 Quite High
Apoptosis 22 81.52 Quite High
Myocardial Infarction 27 78.48 Quite High
Wound Healing 1 76.00 Quite High
INFLAMMATION 14 63.68 Quite High
Critical Illness 9 5.00 Very Low Very Low Very Low
Infarction 7 5.00 Very Low Very Low Very Low
Body Weight 7 5.00 Very Low Very Low Very Low
Starvation 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Yumet and colleagues [13] have recently shown in rats with abdominal sepsis that total GHR numbers are unchanged, with the impaired IGF-I response to GH being temporally related to a defect in STAT5 activation and increased SOCS mRNA expression.
Positive_regulation (activation) of STAT5 associated with sepsis
1) Confidence 0.41 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.46 Pain Relevance 0.11
Using confocal microscopy and Western blotting this study showed that morphine treatment was able to activate cytoplasmic STAT5a in CEM x174 cells, which then translocated into the nucleus and bound to elements of the cyclin D1 promoter.
Positive_regulation (activate) of STAT5a in nucleus associated with morphine
2) Confidence 0.31 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19426693 Disease Relevance 0 Pain Relevance 0.51
EPO signaling involves multiple pathways including activation of STAT 5, activation of proteins with Src homology 2 domains, such as PI3 kinase and activation of ras/MAP kinases[19].
Positive_regulation (activation) of STAT 5
3) Confidence 0.04 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2954875 Disease Relevance 0.49 Pain Relevance 0

General Comments

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