INT159947

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 4.01
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 6
liver 2
Mat1a (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 22 98.92 Very High Very High Very High
Hippocampus 10 86.64 High High
Inflammation 1 51.84 Quite High
adenocard 10 5.00 Very Low Very Low Very Low
Spinal cord 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 95 99.68 Very High Very High Very High
Toxicity 5 99.28 Very High Very High Very High
Hepatotoxicity 2 97.64 Very High Very High Very High
Pressure And Volume Under Development 2 93.12 High High
Disease 190 93.00 High High
Frailty 5 91.04 High High
Cancer 1 89.60 High High
Urological Neuroanatomy 5 85.36 High High
Liver Failure 1 79.12 Quite High
Hyperhomocysteinemia 25 68.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies further examined MAT expression and activity in response to APAP toxicity.
Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (expression) of MAT associated with toxicity and paracetamol
1) Confidence 0.42 Published 2010 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 20450926 Disease Relevance 0.51 Pain Relevance 1.11
In addition they measured the synthesis of AdoMet by adenosyl transferase and AdoMet utilization by COMT, and concluded that the decrease in AdoMet levels was a consequence of increased utilization during aging.
Negative_regulation (adenosyl) of Gene_expression (utilization) of AdoMet associated with aging
2) Confidence 0.37 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.63 Pain Relevance 0.03
The finding that AdoMet levels in APP/PS1 mice are not decreased during aging (in contrast to wild-type mice), is probably related to less demand due to neurodegeneration.
Neg (not) Negative_regulation (decreased) of Gene_expression (levels) of AdoMet associated with aging
3) Confidence 0.33 Published 2009 Journal Neurol Sci Section Abstract Doc Link PMC2746292 Disease Relevance 0.66 Pain Relevance 0
Stramentinoli et al. found decreased AdoMet levels in brain tissue of aging rats [33].
Negative_regulation (decreased) of Gene_expression (levels) of AdoMet in brain associated with aging
4) Confidence 0.32 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.66 Pain Relevance 0
It could be suggested that AdoMet levels in the brain tissue of the APP/PS1 mice, used in this study, do not decrease during aging because of less demand caused by neurodegeneration.
Neg (not) Negative_regulation (decrease) of Gene_expression (levels) of AdoMet in brain associated with aging
5) Confidence 0.32 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.67 Pain Relevance 0.04
However, because of a lack of brain tissue we only measured AdoMet and AdoHcy levels in this experiment.
Negative_regulation (measured) of Gene_expression (levels) of AdoMet in brain
6) Confidence 0.32 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.53 Pain Relevance 0
This work was designed to see whether combination use of Gly and Mat could offer better liver protective and anti-hepatocarcinogenic effects than Gly or Mat alone, and whether it could reduce the adverse effects of Gly alone by acetaminophen-induced hepatotoxicity, diethylnitrosamine-induced hepatocarcinogenesis, induction of immunosuppression, albumen-induced swelling of rat hind paws.
Negative_regulation (reduce) of Gene_expression (effects) of Mat in liver associated with pressure and volume under development, paracetamol and hepatotoxicity
7) Confidence 0.21 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19426721 Disease Relevance 0.35 Pain Relevance 0.27

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