INT159957

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.63
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
spinal cord 2
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 39 100.00 Very High Very High Very High
Spinal cord 7 99.64 Very High Very High Very High
Spontaneous pain 3 98.82 Very High Very High Very High
Brush evoked pain 2 98.40 Very High Very High Very High
Thermal hyperalgesia 9 96.84 Very High Very High Very High
Eae 50 96.72 Very High Very High Very High
allodynia 11 95.84 Very High Very High Very High
Neuropathic pain 21 95.00 High High
Inflammation 14 94.16 High High
Cancer pain 5 92.16 High High
Disease Link Frequency Relevance Heat
Cancer 7 99.48 Very High Very High Very High
Pain 7 98.82 Very High Very High Very High
Neuropathic Pain 39 98.40 Very High Very High Very High
Hyperalgesia 14 96.84 Very High Very High Very High
Injury 61 96.72 Very High Very High Very High
INFLAMMATION 14 94.16 High High
Stress 2 93.04 High High
Cancer Pain 5 92.16 High High
Necrosis 4 84.96 Quite High
Nervous System Injury 19 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, our results indicate that bilateral increase in the level of TNF-?
Positive_regulation (increase) of Phosphorylation (level) of TNF
1) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.98 Pain Relevance 0.68
We have demonstrated that tactile allodynia and spontaneous pain of female rats with tibia tumors were correlated with the increase of both phosphorylated-p38MAPK (p-p38MAPK) and proinflammatory cytokines (IL-1beta and TNF-alpha) in the spinal cord 6 days after Walker 256 cells' inoculation.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of TNF-alpha in spinal cord associated with pain, brush evoked pain, cancer, spontaneous pain, spinal cord and cytokine
2) Confidence 0.23 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.10 Pain Relevance 0.94
Although IkappaB inhibitor suppressed the TNF-alpha-induced IL-6 release, the Rho-kinase inhibitors did not affect the TNF-alpha-induced IkappaB phosphorylation.
Positive_regulation (-) of Phosphorylation (phosphorylation) of TNF-alpha
3) Confidence 0.15 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19427347 Disease Relevance 0.54 Pain Relevance 0.03

General Comments

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