INT159957

Context Info Confidence 0.49 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 2.63 Pain Relevance 1.65

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)

Anatomy Link Frequency spinal cord 2 Tnf (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 39 100.00 Spinal cord 7 99.64 Spontaneous pain 3 98.82 Brush evoked pain 2 98.40 Thermal hyperalgesia 9 96.84 Eae 50 96.72 allodynia 11 95.84 Neuropathic pain 21 95.00 Inflammation 14 94.16 Cancer pain 5 92.16

Disease Link Frequency Relevance Heat Cancer 7 99.48 Pain 7 98.82 Neuropathic Pain 39 98.40 Hyperalgesia 14 96.84 Injury 61 96.72 INFLAMMATION 14 94.16 Stress 2 93.04 Cancer Pain 5 92.16 Necrosis 4 84.96 Nervous System Injury 19 75.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, our results indicate that bilateral increase in the level of TNF-?

Positive_regulation (increase) of Phosphorylation (level) of TNF

1) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.98 Pain Relevance 0.68

We have demonstrated that tactile allodynia and spontaneous pain of female rats with tibia tumors were correlated with the increase of both phosphorylated-p38MAPK (p-p38MAPK) and proinflammatory cytokines (IL-1beta and TNF-alpha) in the spinal cord 6 days after Walker 256 cells' inoculation.

Positive_regulation (increase) of Phosphorylation (phosphorylated) of TNF-alpha in spinal cord associated with pain, brush evoked pain, cancer, spontaneous pain, spinal cord and cytokine

2) Confidence 0.23 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.10 Pain Relevance 0.94

Although IkappaB inhibitor suppressed the TNF-alpha-induced IL-6 release, the Rho-kinase inhibitors did not affect the TNF-alpha-induced IkappaB phosphorylation.

Positive_regulation (-) of Phosphorylation (phosphorylation) of TNF-alpha

3) Confidence 0.15 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19427347 Disease Relevance 0.54 Pain Relevance 0.03

General Comments

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