INT15996

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Context Info
Confidence 0.35
First Reported 1985
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 9
Total Number 14
Disease Relevance 5.66
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
ileum 2
PGE2 2
smooth muscle 1
molar 1
Ltc4s (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 14 99.52 Very High Very High Very High
agonist 78 97.28 Very High Very High Very High
aspirin 19 95.76 Very High Very High Very High
Inflammation 104 94.68 High High
cINOD 7 81.64 Quite High
sodium channel 2 80.40 Quite High
tetrodotoxin 2 79.76 Quite High
peptic ulcer disease 1 79.52 Quite High
antagonist 32 78.64 Quite High
Inflammatory mediators 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 14 99.52 Very High Very High Very High
Ulcers 4 99.36 Very High Very High Very High
Asthma 36 99.12 Very High Very High Very High
Rhinitis 5 98.48 Very High Very High Very High
Injury 13 98.10 Very High Very High Very High
Anaphylaxis 3 97.40 Very High Very High Very High
Duodenal Ulcer 6 96.56 Very High Very High Very High
INFLAMMATION 130 94.68 High High
Edema 24 92.76 High High
Necrosis 1 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The contribution of other products of the various pathways of arachidonic acid metabolism to gastric mucosal injury and the mechanism underlying the close interrelationship between protection and inhibition of LTC4 formation observed with certain compounds remains to be investigated.
LTC4 Binding (formation) of associated with injury
1) Confidence 0.35 Published 1991 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 1782414 Disease Relevance 0.33 Pain Relevance 0.14
These results indicate that there is no association between these two promoter polymorphisms of LTC4S and the phenotype of AIA in a Korean population.
LTC4S Neg (no) Binding (association) of associated with asthma
2) Confidence 0.33 Published 2006 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 16340173 Disease Relevance 0.56 Pain Relevance 0.10
In this paper, we report a new single nucleotide polymorphism (SNP) of the LTC4S promoter, -1702G>A, in AIA patients and evaluate its genetic role in the association with the LTC4S-444 A>C polymorphism.
LTC4S-444 Binding (association) of associated with asthma
3) Confidence 0.29 Published 2006 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 16340173 Disease Relevance 1.02 Pain Relevance 0.37
Fundic LTB4 and LTC4 generation was similar in ulcer patients and controls.
LTC4 Binding (generation) of associated with ulcers
4) Confidence 0.16 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2171135 Disease Relevance 0.84 Pain Relevance 0.08
In contrast, the current study does not corroborate the previous association between SNP LTC4S-rs730012 (also known as -444A/C) and allergic rhinitis [28].
LTC4S Neg (not) Binding (association) of associated with rhinitis
5) Confidence 0.14 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2292155 Disease Relevance 0.64 Pain Relevance 0.03
In the presence of Indo, addition of > or = 10(-8) M of PGE2 suppressed contractions to LTC4 and LTD4.
LTC4 Binding (contractions) of in PGE2
6) Confidence 0.06 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8179018 Disease Relevance 0 Pain Relevance 0.27
These and other studies suggest that LTs are synthesized by canine bronchi and have receptors on canine bronchial smooth muscle but that contractions to LTC4 and LTD4 in the canine airway are usually not observed because of the presence of inhibitory prostanoids (PGE2 and PGI2).
LTC4 Binding (contractions) of in PGE2
7) Confidence 0.05 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8179018 Disease Relevance 0.09 Pain Relevance 0
The spectrum of the bound ligand was essentially identical to that of the free ligand, indicating that the protein binds but does not chemically modify LTC4 (Figure S3).


LTC4 Binding (binds) of
8) Confidence 0.03 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0 Pain Relevance 0.05
When administered to tissue preparations, AnSt-D7L1 abrogated Leukotriene C4 (LTC4)-induced contraction of guinea pig ileum and contraction of rat aorta by the TXA2 analog U46619.
LTC4 Binding (abrogated) of in ileum
9) Confidence 0.03 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2994686 Disease Relevance 0.36 Pain Relevance 0.08
When administered to tissue preparations, AnSt-D7L1 abrogated Leukotriene C4 (LTC4)-induced contraction of guinea pig ileum and contraction of rat aorta by the TXA2 analog U46619.
Leukotriene C4 Binding (abrogated) of in ileum
10) Confidence 0.03 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2994686 Disease Relevance 0.36 Pain Relevance 0.08
CysLT2 binds both LTC4 and LTD4 with an affinity of approximately 10 nM, and both receptors bind LTE4 with affinities near 100 nM [24].
LTC4 Binding (binds) of
11) Confidence 0.03 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.40 Pain Relevance 0.03
In order to obtain crystals with the protein bound to its ligands, either LTC4 or U46619 prepared in 10 mM Tris-HCl pH 8.0 buffer was pre-incubated with AnSt-D7L1 for 10 min but in a 1.3 molar excess when compared to the protein concentration.
LTC4 Binding (bound) of in molar
12) Confidence 0.02 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0 Pain Relevance 0.14
In some endothelial populations, CysLT1 is much more abundant than CysLT2 and has affinities for LTD4 and LTC4 of approximately 1 nM and 10 nM, respectively.
LTC4 Binding (affinities) of
13) Confidence 0.02 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.52 Pain Relevance 0.03
LTC4 and LTD4 collectively account for the biological activity known as slow-reacting substance of anaphylaxis and are potent smooth muscle contracting agents.
LTC4 Binding (account) of in smooth muscle associated with anaphylaxis
14) Confidence 0.02 Published 1985 Journal Fed. Proc. Section Abstract Doc Link 2981730 Disease Relevance 0.53 Pain Relevance 0.26

General Comments

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