INT159962

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 2.70
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Il6) microtubule organizing center (Rock2) cytoplasm (Rock2)
extracellular space (Il6) extracellular region (Il6) nucleus (Rock2)
Rock2 (Rattus norvegicus)
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 6 96.20 Very High Very High Very High
Central nervous system 12 95.48 Very High Very High Very High
Neuropathic pain 3 93.08 High High
Disease Link Frequency Relevance Heat
Necrosis 6 100.00 Very High Very High Very High
Cancer 6 100.00 Very High Very High Very High
Glioma 9 99.64 Very High Very High Very High
Neuropathic Pain 3 93.08 High High
Neurodegenerative Disease 3 92.24 High High
Stroke 3 91.16 High High
Injury 3 90.84 High High
Increased Venous Pressure Under Development 6 87.24 High High
Stress 3 78.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.
Rho-kinase Regulation (Involvement) of Localization (release) of interleukin-6 associated with necrosis, cancer and glioma
1) Confidence 0.09 Published 2009 Journal Neurochem. Int. Section Title Doc Link 19427347 Disease Relevance 0.85 Pain Relevance 0.16
Therefore, we investigated the involvement of Rho-kinase in the TNF-alpha-induced IL-6 release from rat C6 glioma cells.
Rho-kinase Spec (investigated) Regulation (involvement) of Localization (release) of IL-6 associated with glioma
2) Confidence 0.09 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19427347 Disease Relevance 0.93 Pain Relevance 0.36
These results strongly suggest that Rho-kinase regulates the TNF-alpha-induced IL-6 release at a point upstream from p38 MAPK and SAPK/JNK in C6 glioma cells.
Rho-kinase Regulation (regulates) of Localization (release) of IL-6 associated with glioma
3) Confidence 0.09 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19427347 Disease Relevance 0.91 Pain Relevance 0.35

General Comments

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