INT159963

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 2.32
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnf, Il6) extracellular region (Tnf, Il6) signal transduction (Tnf)
aging (Il6) plasma membrane (Tnf) intracellular (Tnf)
Tnf (Rattus norvegicus)
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 6 94.88 High High
Central nervous system 12 94.16 High High
Neuropathic pain 3 91.76 High High
Disease Link Frequency Relevance Heat
Glioma 9 99.48 Very High Very High Very High
Neuropathic Pain 3 91.76 High High
Neurodegenerative Disease 3 90.92 High High
Stroke 3 89.84 High High
Injury 3 89.52 High High
Necrosis 6 88.04 High High
Cancer 6 87.68 High High
Stress 3 86.00 High High
Increased Venous Pressure Under Development 6 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although IkappaB inhibitor suppressed the TNF-alpha-induced IL-6 release, the Rho-kinase inhibitors did not affect the TNF-alpha-induced IkappaB phosphorylation.
TNF-alpha Positive_regulation (induced) of Localization (release) of IL-6
1) Confidence 0.12 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19427347 Disease Relevance 0.49 Pain Relevance 0
These results strongly suggest that Rho-kinase regulates the TNF-alpha-induced IL-6 release at a point upstream from p38 MAPK and SAPK/JNK in C6 glioma cells.
TNF-alpha Positive_regulation (induced) of Localization (release) of IL-6 associated with glioma
2) Confidence 0.12 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19427347 Disease Relevance 0.91 Pain Relevance 0.35
Therefore, we investigated the involvement of Rho-kinase in the TNF-alpha-induced IL-6 release from rat C6 glioma cells.
TNF-alpha Spec (investigated) Positive_regulation (induced) of Localization (release) of IL-6 associated with glioma
3) Confidence 0.12 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19427347 Disease Relevance 0.93 Pain Relevance 0.36

General Comments

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