INT159964

Context Info Confidence 0.11 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.94 Pain Relevance 0.29

signal transduction (Tnf, Mapk8) mitochondrion (Mapk8) intracellular (Tnf) extracellular matrix organization (Tnf) cytoplasm (Mapk8) cytosol (Mapk8)

Tnf (Rattus norvegicus) Mapk8 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Central nervous system 4 91.20 Neuropathic pain 1 82.96 cytokine 2 79.20

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 2 94.88 Injury 1 86.64 Stress 1 86.48 Stroke 1 86.00 Neurodegenerative Disease 1 85.36 Neuropathic Pain 1 82.96 Glioma 3 75.00 Necrosis 2 75.00 Cancer 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The Rho-kinase inhibitors attenuated the TNF-alpha-induced phosphorylation of both p38 MAP kinase and SAPK/JNK.

TNF-alpha Positive_regulation (induced) of Phosphorylation (phosphorylation) of JNK

1) Confidence 0.11 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19427347 Disease Relevance 0.94 Pain Relevance 0.29

General Comments

This test has worked.