INT159988

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 2.90
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsk) extracellular space (Ctsk) lysosome (Ctsk)
cytoplasm (Ctsk)
Anatomy Link Frequency
Osteoclasts 3
lacuna 2
brains 1
meibomian gland 1
Ctsk (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 66 100.00 Very High Very High Very High
Inflammation 20 93.68 High High
Enkephalin 4 93.68 High High
Tendonitis 3 86.24 High High
Neuropeptide 2 77.64 Quite High
cytokine 14 73.44 Quite High
Opioid 1 45.04 Quite Low
anesthesia 2 42.56 Quite Low
rheumatoid arthritis 38 20.44 Low Low
Osteoarthritis 19 20.16 Low Low
Disease Link Frequency Relevance Heat
Disorders Of The Lacrimal System 85 99.82 Very High Very High Very High
Disease 23 98.84 Very High Very High Very High
Schizophrenia 4 97.66 Very High Very High Very High
Osteoporosis 122 97.48 Very High Very High Very High
Syndrome 2 96.00 Very High Very High Very High
Apoptosis 30 95.40 Very High Very High Very High
INFLAMMATION 22 93.68 High High
Hypercalcemia 15 90.08 High High
Tendinopathy 3 86.24 High High
Targeted Disruption 25 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, concentrated BAL supernatants of mice of both experimental groups were found to contain cathepsin K protein, suggesting that under baseline conditions, low levels of cathepsin K protein is also released into the bronchoalveolar compartment (Figure 1E).
Localization (released) of cathepsin K
1) Confidence 0.70 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.21 Pain Relevance 0
Osteoclasts were shown to synthesize and secrete cathepsin K (CatK) into the extracellular compartment at the attachment site between osteoclasts and the bone surface [19].
Localization (secrete) of CatK in Osteoclasts
2) Confidence 0.69 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.08 Pain Relevance 0
According to Väänänen et al [32], a high level of CatK expression secreted by osteoclasts in the lacuna is an indicator of the resorption process.
Localization (secreted) of CatK in lacuna
3) Confidence 0.69 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.46 Pain Relevance 0.09
Osteoclasts were shown to synthesize and secrete cathepsin K (CatK) into the extracellular compartment at the attachment site between osteoclasts and the bone surface [19].
Localization (secrete) of cathepsin K in Osteoclasts
4) Confidence 0.69 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.08 Pain Relevance 0
Mature osteoclasts capable of resorption secrete cathepsin K into the resorption lacuna [25].
Localization (secrete) of cathepsin K in osteoclasts
5) Confidence 0.68 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2703200 Disease Relevance 0.48 Pain Relevance 0
-estradiol, in the meibomian gland include secreted acidic cysteine rich glycoprotein (regulates cell growth [71]), vascular endothelial growth factor A (promotes cell migration, among many other actions [71]), matrix metalloproteinase 3 (degrades fibronectin, laminin, gelatins and collagens [71]) and cathepsin K (degrades extracellular matrices [71]).
Localization (secreted) of cathepsin K in meibomian gland associated with disorders of the lacrimal system and metalloproteinase
6) Confidence 0.32 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.95 Pain Relevance 0.19
To verify if this process might possibly contribute in the pathogenesis of schizophrenia post mortem brains of patients suffering from this disease were analysed immunohistochemically for the presence and co-localization of cathepsin K and beta-EP.
Spec (analysed) Localization (co-localization) of cathepsin K in brains associated with disease and schizophrenia
7) Confidence 0.24 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19428782 Disease Relevance 0.41 Pain Relevance 0.26
Then proteolytic enzymes expressed in osteoclasts, such as cathepsin K and MMPs (MMP-13, MMP-2 and MMP-9), are secreted into the lacuna for removal of bone mineral and degradation of organic matrix protein [32].
Localization (secreted) of cathepsin K in lacuna associated with metalloproteinase
8) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.24 Pain Relevance 0.21

General Comments

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