INT159989

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 25
Disease Relevance 10.51
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsk) extracellular space (Ctsk) lysosome (Ctsk)
cytoplasm (Ctsk)
Anatomy Link Frequency
osteoclast 7
lung 6
alveolar macrophages 4
osteoblasts 2
leukocyte 1
Ctsk (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 98 99.26 Very High Very High Very High
fibrosis 364 97.88 Very High Very High Very High
Opioid 1 96.16 Very High Very High Very High
Tendonitis 9 95.60 Very High Very High Very High
Enkephalin 4 89.40 High High
anesthesia 28 70.48 Quite High
halothane 14 20.76 Low Low
imagery 14 12.76 Low Low
isoflurane 14 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 351 100.00 Very High Very High Very High
INFLAMMATION 98 99.26 Very High Very High Very High
Schizophrenia 4 99.00 Very High Very High Very High
Pulmonary Fibrosis 322 98.08 Very High Very High Very High
Osteoporosis 351 97.16 Very High Very High Very High
Fibrosis 70 96.12 Very High Very High Very High
Tendinopathy 9 95.60 Very High Very High Very High
Airway Obstruction 14 80.04 Quite High
Low Back Pain 1 78.32 Quite High
Necrosis 2 75.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also observed increased cathepsin K protein contents and proteolytic activities in cell-free BAL fluid concentrates prepared from the lungs of mock-treated and bleomycin-treated cath K tg relative to wild-type mice (Figure 3E, F).
Positive_regulation (increased) of cathepsin K in lungs
1) Confidence 0.69 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.28 Pain Relevance 0.07
Also, an increased bleomycin-triggered inflammatory lung leukocyte recruitment carrying increased cathepsin K protein cargo into the lungs might additionally or alternatively underly the lower collagen contents observed in the transgenic mice.
Positive_regulation (increased) of cathepsin K in leukocyte associated with targeted disruption and inflammation
2) Confidence 0.69 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.41 Pain Relevance 0.05
Finally, the activation of the Opn gene in osteoblasts and CatK in osteoclasts supported the identification of each cell type.


Positive_regulation (activation) of CatK in osteoclasts
3) Confidence 0.68 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.34 Pain Relevance 0
The activation of Opn demonstrates that the cells have differentiated into osteoblasts, while the activation of CatK indicates osteoclast differentiation.
Positive_regulation (activation) of CatK in osteoblasts
4) Confidence 0.68 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.40 Pain Relevance 0
Differentiation of mononucleated cells into mature osteoclasts was indicated by the activation of the CatK gene.
Positive_regulation (activation) of CatK in osteoclasts
5) Confidence 0.68 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.42 Pain Relevance 0
Our study shows that the activation of CatK was found only in mononucleated cells after 10 days cultured in osteoclast differentiation media.
Positive_regulation (activation) of CatK in osteoclast
6) Confidence 0.68 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.35 Pain Relevance 0.10
In this study, we showed that Opn and CatK genes were activated in the primary mononucleated cells that had been differentiated into osteoblasts and osteoclasts, respectively.
Positive_regulation (activated) of CatK in osteoclasts
7) Confidence 0.68 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.42 Pain Relevance 0
These data suggest a protective role of increased cathepsin K levels to antagonize excessive ECM deposition in diseased lungs.


Positive_regulation (increased) of cathepsin K in lungs
8) Confidence 0.46 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.55 Pain Relevance 0.09
Analysis of cathepsin K mRNA and protein levels in lysates of resident alveolar macrophages and lung homogenates revealed 9.3-fold and 6.4-fold upregulated cathepsin K mRNA levels in alveolar macrophages and lung homogenates, respectively of the transgenic mice as compared to mock-treated wild-type mice (Figure 1A).
Positive_regulation (upregulated) of cathepsin K mRNA in lung associated with targeted disruption
9) Confidence 0.46 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.19 Pain Relevance 0.07
One unresolved question of the current study is the identification of the mechanism by which bleomycin challenge further increased cathepsin K mRNA and protein levels both in wild-type mice and in transgenic mice.
Positive_regulation (increased) of cathepsin K mRNA associated with targeted disruption
10) Confidence 0.46 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.67 Pain Relevance 0.18
Cathepsin K protein levels were strongly increased in alveolar macrophages and lung parenchymal tissue of mock-treated cathepsin K transgenic (cath K tg) mice relative to wild-type mice and further increased particularly in cath K tg but also wild-type mice in response to bleomycin.
Positive_regulation (increased) of Cathepsin K in lung associated with targeted disruption
11) Confidence 0.46 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2490691 Disease Relevance 0.85 Pain Relevance 0.24
Therefore, we questioned whether this effect might be due to further bleomycin-induced upregulation of cathepsin K protein in the transgenic mice as opposed to bleomycin-challenged wild-type mice.
Positive_regulation (upregulation) of cathepsin K associated with targeted disruption
12) Confidence 0.46 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.40 Pain Relevance 0.05
Since in the current study, numbers of BAL fluid cell differentials were similar in the transgenic mice compared to wild-type mice upon bleomycin treatment, the data suggest that primarily the transgene-induced increased cathepsin K translation in alveolar macrophages rather than differential leukocyte mobilization towards the lungs of mice per se was responsible for the reduced collagen deposition in the transgenic as compared to wild-type mice challenged with bleomycin.
Positive_regulation (increased) of cathepsin K in alveolar macrophages associated with targeted disruption
13) Confidence 0.46 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.42 Pain Relevance 0.08
Thus, as opposed to human or murine lung fibroblasts [8] or human bronchial epithelial cells [7], type II epithelial cells do not appear to contribute to cathepsin K-dependent collagenolytic activities in bleomycin-induced lung fibrosis.
Positive_regulation (contribute) of cathepsin K-dependent in lung associated with fibrosis and pulmonary fibrosis
14) Confidence 0.46 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.33 Pain Relevance 0.05
Also, baseline cathepsin K protein levels were strongly increased in the respective samples collected from cath K overexpressing mice when compared to wild-type mice (Figure 1B, D).
Positive_regulation (increased) of cathepsin K
15) Confidence 0.46 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.18 Pain Relevance 0.06
Cathepsin K protein levels were strongly increased in alveolar macrophages and lung parenchymal tissue of mock-treated cathepsin K transgenic (cath K tg) mice relative to wild-type mice and further increased particularly in cath K tg but also wild-type mice in response to bleomycin.
Positive_regulation (increased) of Cathepsin K in lung associated with targeted disruption
16) Confidence 0.46 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2490691 Disease Relevance 0.88 Pain Relevance 0.25
Activation of Opn, CatK, Sca-1 and Gapdh Genes
Positive_regulation (Activation) of CatK
17) Confidence 0.45 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.15 Pain Relevance 0
On the other hand, the significant increment of TRAP activity and the activation of CatK during osteoclast differentiation reflected the increased number of fully differentiated osteoclasts.
Positive_regulation (activation) of CatK in osteoclast
18) Confidence 0.45 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.06 Pain Relevance 0
The osteoclast-specific CatK gene was only upregulated in mononucleated cells.
Positive_regulation (upregulated) of CatK in osteoclast
19) Confidence 0.45 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC2984396 Disease Relevance 0.09 Pain Relevance 0
In this study, we showed that Opn and CatK genes were activated in the primary mononucleated cells that had been differentiated into osteoblasts and osteoclasts, respectively.
Positive_regulation (activated) of CatK in osteoblasts
20) Confidence 0.23 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.42 Pain Relevance 0

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