INT160

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Context Info
Confidence 0.62
First Reported 1970
Last Reported 2006
Negated 17
Speculated 7
Reported most in Abstract
Documents 37
Total Number 44
Disease Relevance 7.56
Pain Relevance 20.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 20
neurons 6
pituitary 4
blood 2
Dorsal 2
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 70 100.00 Very High Very High Very High
narcan 53 100.00 Very High Very High Very High
antagonist 28 100.00 Very High Very High Very High
Enkephalin 14 100.00 Very High Very High Very High
opioid receptor 5 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
Acupuncture 2 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High
analgesia 1 100.00 Very High Very High Very High
anesthesia 17 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Congenital Anomalies 5 100.00 Very High Very High Very High
Pain 1 100.00 Very High Very High Very High
Galactorrhea 31 99.90 Very High Very High Very High
Depression 14 99.64 Very High Very High Very High
Headache 12 98.98 Very High Very High Very High
Pituitary Cancer 3 98.24 Very High Very High Very High
Endometriosis (extended) 1 98.20 Very High Very High Very High
Stress 17 97.78 Very High Very High Very High
Schizophrenia 1 97.56 Very High Very High Very High
Acute Coronary Syndrome 7 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was found that a prolonged immobilization stressful procedure for 5 h inhibited the response to morphine and fentanyl to increase prolactin secretion, but did not influence the increase in plasma prolactin caused by haloperidol.
Neg (not) Regulation (influence) of Positive_regulation (increase) of prolactin in plasma associated with morphine
1) Confidence 0.62 Published 1984 Journal J. Endocrinol. Section Abstract Doc Link 6716033 Disease Relevance 0.15 Pain Relevance 0.43
There was no effect of pyridoxine on elevated plasma PRL in any of the nine hyperprolactinemic subjects.
Neg (no) Regulation (effect) of Positive_regulation (elevated) of PRL in plasma
2) Confidence 0.61 Published 1978 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 755053 Disease Relevance 0.38 Pain Relevance 0.09
We investigated the effects of immunoneutralization of dynorphin, leu-enkephalin and met-enkephalin on the suckling-induced prolactin increase and on the activity of the TIDA neurons in lactating female rats between days 7 and 12 postpartum.
Spec (investigated) Regulation (effects) of Positive_regulation (increase) of prolactin in neurons associated with dynorphin and enkephalin
3) Confidence 0.60 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 10773747 Disease Relevance 0 Pain Relevance 0.50
The increase in prolactin level is probably not directly involved in normal secretion of LH and follicle stimulating hormone (FSH) at ovulation.
Neg (not) Regulation (involved) of Positive_regulation (increase) of prolactin in follicle
4) Confidence 0.58 Published 1980 Journal J. Reprod. Fertil. Section Abstract Doc Link 6776267 Disease Relevance 0.29 Pain Relevance 0.27
Histidine alone did not affect plasma levels of prolactin or methyldopamine-induced increase in plasma prolactin levels.
Neg (not) Regulation (affect) of Positive_regulation (increase) of plasma prolactin in plasma
5) Confidence 0.53 Published 1976 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 14035 Disease Relevance 0 Pain Relevance 0.19
Atropine reduces the increase in PRL levels caused by thiopental and ketamine, while it does not affect PRL high levels induced by dehydrobenzperidine.
Neg (not) Regulation (affect) of Neg (not) Positive_regulation (induced) of PRL associated with ketamine
6) Confidence 0.52 Published 1989 Journal Middle East J Anesthesiol Section Abstract Doc Link 2811781 Disease Relevance 0 Pain Relevance 0.36
The effect of immunoneutralization of beta-endorphin on the suckling-induced prolactin increase and on the activity of the tuberoinfundibular dopaminergic (TIDA) neurons was determined in lactating female rats between days 8 - 12 post-partum.
Regulation (effect) of Positive_regulation (increase) of prolactin in neurons
7) Confidence 0.47 Published 1997 Journal Life Sci. Section Abstract Doc Link 9324072 Disease Relevance 0 Pain Relevance 0.18
We explored the role of the opioid system and the participation of ovarian hormones in the regulation of prolactin induced by the suckling stimulus at the end of pregnancy in rats with developed maternal behavior, and during lactation.
Regulation (regulation) of Positive_regulation (induced) of prolactin associated with opioid
8) Confidence 0.45 Published 2002 Journal J. Endocrinol. Section Abstract Doc Link 11834443 Disease Relevance 0 Pain Relevance 0.37
The acute desensitization after a single injection of nicotine appears to be specific to release of prolactin by nicotine because the prolactin response to morphine was unaffected 1 hr after injection of nicotine.
Neg (unaffected) Regulation (unaffected) of Positive_regulation (response) of prolactin associated with nicotine and morphine
9) Confidence 0.45 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2299587 Disease Relevance 0 Pain Relevance 0.93
Pretreatment with 5-MeODMT reduced prolactin release by agents that depend on serotonergic neurotransmission for part of their prolactin release stimulation.
Regulation (depend) of Positive_regulation (stimulation) of prolactin
10) Confidence 0.45 Published 1982 Journal Life Sci. Section Abstract Doc Link 7154858 Disease Relevance 0 Pain Relevance 0.34
The effect of magnesium aspartate, xylazine and morphine on the immobilization-induced increase in the levels of prolactin in turkey plasma.
Regulation (effect) of Positive_regulation (increase) of prolactin in plasma associated with morphine
11) Confidence 0.45 Published 1987 Journal J. Vet. Pharmacol. Ther. Section Title Doc Link 3612939 Disease Relevance 0 Pain Relevance 0.32
The present study was undertaken to investigate whether headache in women with nonpuerperal hyperprolactinemia was related to elevated serum prolactin (PRL) levels or the presence of a PRL-secreting pituitary adenoma.
Spec (whether) Regulation (related) of Spec (whether) Positive_regulation (elevated) of PRL in pituitary associated with galactorrhea, pituitary cancer and headache
12) Confidence 0.45 Published 1986 Journal Obstet Gynecol Section Abstract Doc Link 3737035 Disease Relevance 0.91 Pain Relevance 0.25
Naloxone-sensitive endogenous opioids do not appear to be involved in the control of the PRL rise induced by breast stimulation.
Regulation (control) of Positive_regulation (induced) of PRL associated with endogenous opioid and narcan
13) Confidence 0.45 Published 1994 Journal Life Sci. Section Abstract Doc Link 8107524 Disease Relevance 0 Pain Relevance 0.56
The present study was undertaken to investigate whether headache in women with nonpuerperal hyperprolactinemia was related to elevated serum prolactin (PRL) levels or the presence of a PRL-secreting pituitary adenoma.
Spec (whether) Regulation (related) of Spec (whether) Positive_regulation (elevated) of prolactin in pituitary associated with galactorrhea, pituitary cancer and headache
14) Confidence 0.45 Published 1986 Journal Obstet Gynecol Section Abstract Doc Link 3737035 Disease Relevance 0.91 Pain Relevance 0.25
Coinfusion of 100 micrograms/h of naloxone with the high dose of each of the agonists completely blocked the responses of both hormones to each of the agonists with one exception: the highly variable stimulation of PRL by U50,488H was not affected, thus indicating a nonspecific effect of U50,488H on PRL secretion.
Neg (not) Regulation (affected) of Neg (exception) Positive_regulation (stimulation) of PRL associated with agonist and narcan
15) Confidence 0.45 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3033534 Disease Relevance 0 Pain Relevance 0.33
Pilocarpine also inhibited the release of prolactin induced by beta-endorphin or metoclopramide without affecting the basal and haloperidol-stimulated serum prolactin levels.
Neg (without) Regulation (affecting) of Positive_regulation (haloperidol-stimulated) of prolactin
16) Confidence 0.45 Published 1979 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 503252 Disease Relevance 0 Pain Relevance 0.56
To address this hypothesis, we investigated the effects of various opioid receptor antagonists on suckling-induced prolactin (PRL) and LH responses in primiparous, lactating rats.
Spec (investigated) Regulation (effects) of Positive_regulation (induced) of PRL associated with antagonist and opioid receptor
17) Confidence 0.45 Published 1991 Journal Brain Res. Section Abstract Doc Link 1667901 Disease Relevance 0.09 Pain Relevance 0.50
To address this hypothesis, we investigated the effects of various opioid receptor antagonists on suckling-induced prolactin (PRL) and LH responses in primiparous, lactating rats.
Spec (investigated) Regulation (effects) of Positive_regulation (induced) of prolactin associated with antagonist and opioid receptor
18) Confidence 0.45 Published 1991 Journal Brain Res. Section Abstract Doc Link 1667901 Disease Relevance 0.09 Pain Relevance 0.50
Dorsal hippocampal implants were without any effect on the morphine-induced GH, PRL or B secretion.
Neg (without) Regulation (effect) of Positive_regulation (morphine-induced) of PRL in Dorsal associated with morphine
19) Confidence 0.45 Published 1991 Journal Brain Res. Section Abstract Doc Link 1664769 Disease Relevance 0.08 Pain Relevance 1.26
Therefore, PRL surges induced by PHB administration will be solely responsible for the luteal functionalization in PHB-PSP rats.
Regulation (responsible) of Positive_regulation (induced) of PRL in PSP
20) Confidence 0.44 Published 1980 Journal Endocrinol. Jpn. Section Abstract Doc Link 6780329 Disease Relevance 0 Pain Relevance 0.07

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