INT160009

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.43
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1B) endosome (CDKN1B) nucleoplasm (CDKN1B)
nucleus (CDKN1B) cell cycle (CDKN1B) kinase activity (CDKN1B)
CDKN1B (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 12 99.36 Very High Very High Very High
Arthritis 106 91.52 High High
cINOD 11 90.60 High High
Inflammation 19 83.12 Quite High
COX-2 inhibitor 1 77.64 Quite High
diclofenac 1 75.96 Quite High
acular 2 74.92 Quite High
metalloproteinase 4 54.84 Quite High
cytokine 17 53.80 Quite High
methotrexate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 3 94.76 High High
Apoptosis 18 94.24 High High
Rheumatoid Arthritis 103 91.52 High High
INFLAMMATION 25 83.12 Quite High
Death 6 80.64 Quite High
Osteoporosis 1 62.96 Quite High
Arthritis 5 59.00 Quite High
Reprotox - General 1 2 43.28 Quite Low
Disease 12 22.44 Low Low
Cancer 11 11.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We further found that indomethacin, celecoxib and dexamethasone increased the mRNA and protein expressions of p27(kip1) and decreased those of cyclin D2 and p-cdk2 in hOBs.
Transcription (expressions) of kip1 associated with dexamethasone
1) Confidence 0.67 Published 2009 Journal Toxicology Section Abstract Doc Link 19428934 Disease Relevance 0.97 Pain Relevance 1.09
Unphosphorylated active FOXO family proteins promote transcription of genes that regulate cell-cycle progression and survival, including CDKN1B [84], FASLG and BCL2L11 [85], which also have been listed in the map.
Transcription (transcription) of CDKN1B
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.47 Pain Relevance 0.21

General Comments

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