INT160012

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.17
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1B) endosome (CDKN1B) nucleoplasm (CDKN1B)
nucleus (CDKN1B) cell cycle (CDKN1B) kinase activity (CDKN1B)
Anatomy Link Frequency
HT-29 2
CDKN1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 11 100.00 Very High Very High Very High
dexamethasone 5 96.80 Very High Very High Very High
COX-2 inhibitor 1 66.76 Quite High
diclofenac 1 65.08 Quite High
acular 2 64.04 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 72 89.60 High High
Necrosis 1 83.88 Quite High
INFLAMMATION 9 75.00 Quite High
Colon Cancer 75 74.72 Quite High
Death 18 69.76 Quite High
Cancer 78 64.72 Quite High
Osteoporosis 1 52.08 Quite High
Malaria 9 5.00 Very Low Very Low Very Low
Toxicity 6 5.00 Very Low Very Low Very Low
Hepatitis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the replenishment of PGE1, PGE2 or PGF2alpha did not reverse the effects of AIDs on proliferation and expressions of p27(kip1) and cyclin D2 in hOBs.
Neg (not) Regulation (effects) of Gene_expression (expressions) of kip1 associated with cinod
1) Confidence 0.44 Published 2009 Journal Toxicology Section Abstract Doc Link 19428934 Disease Relevance 0.85 Pain Relevance 1.04
The pre-treatment of cells with CQ inhibited the down-regulation of p21Cip1 and p27Kip1 expressions induced by 5-FU and, on the other hand, inhibited the up-regulation of the expression of CDK2.
Regulation (regulation) of Gene_expression (expressions) of p27Kip1
2) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0 Pain Relevance 0
Therefore, the up-regulation of p21Cip1 and p27Kip1 expressions in HT-29 cells induced by CQ, possibly contributed to the potentiation of the inhibitory effect of 5-FU, by promoting the cell cycle arrest to G0/G1 phase.
Regulation (regulation) of Gene_expression (expressions) of p27Kip1 in HT-29
3) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.13 Pain Relevance 0
Pre-treatment of cells with CQ inhibited the down-regulation of p21Cip1 and p27Kip1 expression induced by 5-FU and, on the other hand, decreased the expression of CDK2 (Fig. 7).
Regulation (regulation) of Gene_expression (expression) of p27Kip1
4) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.19 Pain Relevance 0

General Comments

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