INT160021

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.42
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc12a4) transmembrane transport (Slc12a4)
Anatomy Link Frequency
dorsal horn 1
urine 1
Slc12a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 4 99.12 Very High Very High Very High
Inflammation 2 97.20 Very High Very High Very High
Face pain 2 96.68 Very High Very High Very High
GABAergic 1 89.76 High High
Hyperalgesia 2 87.24 High High
Spontaneous pain 1 62.84 Quite High
IPN 1 37.72 Quite Low
Central nervous system 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
potassium channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 97.20 Very High Very High Very High
Facial Pain 2 96.68 Very High Very High Very High
Hyperalgesia 2 87.24 High High
Peripheral Arterial Disease 1 74.12 Quite High
Pain 1 62.36 Quite High
Hypersensitivity 1 46.92 Quite Low
Myelodysplastic Syndromes 4 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If 50 µM bumetanide inhibited KCC, we would have expected to observe a smaller inhibition of urine responses than with 10 µM bumetanide because 50 µM bumetanide would have been altering both the influx and the efflux of Cl?.
Negative_regulation (inhibited) of KCC in urine
1) Confidence 0.06 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2806418 Disease Relevance 0 Pain Relevance 0
Therefore, it appears that 50 µM bumetanide only inhibited NKCC and not any KCC.
Negative_regulation (inhibited) of KCC
2) Confidence 0.06 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2806418 Disease Relevance 0 Pain Relevance 0
Down-regulation of K+ -Cl- co-transporter 2 in mouse medullary dorsal horn contributes to the formalin-induced inflammatory orofacial pain.
Negative_regulation (Down-regulation) of co-transporter in dorsal horn associated with inflammation, face pain and dorsal horn
3) Confidence 0.04 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19429157 Disease Relevance 0.42 Pain Relevance 0.47

General Comments

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