INT160023

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 8.41
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp4) plasma membrane (Aqp4) protein complex (Aqp4)
transmembrane transport (Aqp4) cytoplasm (Aqp4)
Anatomy Link Frequency
T cell 2
nerve 1
subfornical organ 1
astrocytes 1
prefrontal 1
Aqp4 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 18 99.64 Very High Very High Very High
opioid receptor 18 99.40 Very High Very High Very High
depression 6 99.08 Very High Very High Very High
Sciatica 2 98.96 Very High Very High Very High
Neuropathic pain 17 96.04 Very High Very High Very High
Spinal cord 52 95.40 Very High Very High Very High
Inflammation 48 94.88 High High
Dopamine 12 94.80 High High
analgesia 6 92.96 High High
Central nervous system 37 92.52 High High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 93 99.80 Very High Very High Very High
Injury 51 99.56 Very High Very High Very High
Glioblastoma 3 99.28 Very High Very High Very High
Depression 6 99.08 Very High Very High Very High
Nerve Root Compression 2 98.96 Very High Very High Very High
Neuropathic Pain 30 97.24 Very High Very High Very High
Pressure And Volume Under Development 27 97.12 Very High Very High Very High
Targeted Disruption 28 96.84 Very High Very High Very High
Brain Injury 2 96.68 Very High Very High Very High
Syndrome 2 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, AQP4 deficiency did not affect chronic morphine-induced alterations of opioid receptor characteristics.
Neg (not) Regulation (affect) of AQP4 associated with opioid receptor and morphine
1) Confidence 0.45 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19429174 Disease Relevance 0.14 Pain Relevance 0.90
Effects of aquaporin4 deficiency on opioid receptors characteristics in naive and chronic morphine-treated mice.
Regulation (Effects) of aquaporin4 associated with opioid receptor and morphine
2) Confidence 0.45 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19429174 Disease Relevance 0.15 Pain Relevance 0.85
Moreover, in glioblastoma it was recently demonstrated an up-regulation and redistribution of AQP4 accompanied by a loss of its polarized expression pattern and so the evidence for a role of it in vasogenic edema formation [80, 102, 104].
Regulation (regulation) of AQP4 associated with pressure and volume under development and glioblastoma
3) Confidence 0.41 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.55 Pain Relevance 0.15
AQP4 is an astrocytic water channel protein that is typically up-regulated in activated astrocytes.
Regulation (regulated) of AQP4 in astrocytes
4) Confidence 0.39 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.29 Pain Relevance 0.72
They aimed to identify significative alteration of AQP4 in a rat model of lumbar radiculopathy (L5 nerve root ligation) and neuropathy (L5 spinal nerve transection).
Regulation (alteration) of AQP4 in nerve associated with neuropathic pain and sciatica
5) Confidence 0.23 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.29 Pain Relevance 0.76
Models that target AQP4 have met with modest success [10], [11], [12].
Regulation (target) of AQP4
6) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 1.52 Pain Relevance 0.31
Immunodominant T Cell Determinants of Aquaporin-4, the Autoantigen Associated with Neuromyelitis Optica

Autoantibodies that target the water channel aquaporin-4 (AQP4) in neuromyelitis optica (NMO) are IgG1, a T cell-dependent Ig subclass.

Regulation (target) of aquaporin-4 in T cell associated with neuromyelitis optica
7) Confidence 0.20 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2994828 Disease Relevance 0.96 Pain Relevance 0.09
Immunodominant T Cell Determinants of Aquaporin-4, the Autoantigen Associated with Neuromyelitis Optica

Autoantibodies that target the water channel aquaporin-4 (AQP4) in neuromyelitis optica (NMO) are IgG1, a T cell-dependent Ig subclass.

Regulation (target) of AQP4 in T cell associated with neuromyelitis optica
8) Confidence 0.20 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2994828 Disease Relevance 0.96 Pain Relevance 0.09
In addition, the basolateral membrane of the ependymal cells that line the subfornical organ is positive for AQP4 [94].
Regulation (positive) of AQP4 in subfornical organ
9) Confidence 0.19 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.09 Pain Relevance 0
A maximal increase of prefrontal NE release was observed in control animals in response to both rewarding and aversive highly salient stimuli (WCh and IPL), and in stressed animals exposed to rewarding or aversive mildly salient stimuli (Fig. 1).
Regulation (response) of WCh in prefrontal
10) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516177 Disease Relevance 0 Pain Relevance 0.05
However, mechanisms of AQP-4 modulation of cortical spreading depression (CSD) remain unclear.
Regulation (modulation) of AQP-4 associated with depression
11) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.47 Pain Relevance 0.28

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