INT16003

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Context Info
Confidence 0.65
First Reported 1991
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 4.68
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Phex) Golgi apparatus (Phex) endoplasmic reticulum (Phex)
Anatomy Link Frequency
osteoblasts 3
osteocyte 2
Hyp3 1
Neutrophil 1
Phex (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 3 99.08 Very High Very High Very High
Enkephalin 5 97.20 Very High Very High Very High
Neurotransmitter 1 94.08 High High
Antinociceptive 2 93.92 High High
Neuropeptide 1 84.92 Quite High
Pain 5 32.00 Quite Low
narcan 1 25.00 Low Low
nociceptor 1 25.00 Low Low
Somatostatin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 365 100.00 Very High Very High Very High
Hypercalcemia 15 95.12 Very High Very High Very High
Hypophosphatemia 55 89.20 High High
Cancer 60 80.88 Quite High
Paraneoplastic Syndromes 5 77.12 Quite High
Disease 50 76.08 Quite High
Ossifying Fibroma 5 66.72 Quite High
Familial Hypophosphatemia 15 66.36 Quite High
Growth Problems 5 63.20 Quite High
Congenital Anomalies 15 42.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As with PHEX and FGF23, DMP1 is highly expressed in cells of the osteoblasts/osteocyte lineage.
Gene_expression (expressed) of PHEX in osteoblasts
1) Confidence 0.65 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.44 Pain Relevance 0
The encoded endopeptidase (PHEX) is membrane-bound and expressed mainly by osteoblasts in bone and odontoblasts in teeth, with no expression in the kidney [18].
Neg (no) Gene_expression (expressed) of PHEX in osteoblasts
2) Confidence 0.58 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.96 Pain Relevance 0
It is of interest that the mRNA of all three factors (FGF23, PHEX and DMP1) involved in the pathogenesis of hypophosphataemic rickets are highly expressed in cells of the osteoblasts/osteocyte lineage.
Gene_expression (expressed) of PHEX in osteocyte associated with rickets
3) Confidence 0.58 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.42 Pain Relevance 0
As with PHEX and FGF23, DMP1 is highly expressed in cells of the osteoblasts/osteocyte lineage.
Gene_expression (expressed) of PHEX in osteocyte
4) Confidence 0.22 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.44 Pain Relevance 0
It is of interest that the mRNA of all three factors (FGF23, PHEX and DMP1) involved in the pathogenesis of hypophosphataemic rickets are highly expressed in cells of the osteoblasts/osteocyte lineage.
Gene_expression (expressed) of PHEX in osteoblasts associated with rickets
5) Confidence 0.20 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.42 Pain Relevance 0
[Hyp3]-tuftsin (Thr-Lys-Hyp-Arg) has been synthesized by the liquid-phase method.
Gene_expression (synthesized) of Thr-Lys-Hyp-Arg in Hyp3
6) Confidence 0.04 Published 1991 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 1783492 Disease Relevance 0 Pain Relevance 0.09
Neutrophil neutral endopeptidase variation and its regulation by opioid peptides.
Gene_expression (variation) of Neutrophil neutral endopeptidase in Neutrophil associated with opioid
7) Confidence 0.01 Published 2001 Journal Int. Immunopharmacol. Section Title Doc Link 11367540 Disease Relevance 0 Pain Relevance 0.68

General Comments

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