INT160037

Context Info Confidence 0.21 First Reported 2008 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.22 Pain Relevance 0.05

peptidase activity (Tpsab1) extracellular region (Tpsab1)

Anatomy Link Frequency colons 2 mast cells 2 Tpsab1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 3 54.32 ischemia 47 53.44 spastic colon 1 50.00 Inflammation 9 5.00 cva 5 5.00 Inflammatory mediators 3 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 1 82.44 Diarrhoea 2 81.80 Cv Unclassified Under Development 29 53.44 Reperfusion Injury 29 50.00 Functional Bowel Disorder 1 50.00 Cv General 4 Under Development 17 5.00 Injury 13 5.00 INFLAMMATION 12 5.00 Pressure And Volume Under Development 3 5.00 Hemorrhage 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We calculated the tryptase positive mast cells in 5 representative areas at 400× magnification by Image-Pro Plus 5.0 (USA) Statistics

Regulation (calculated) of Gene_expression (mast cells) of tryptase in mast cells

1) Confidence 0.21 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 0.05 Pain Relevance 0.05

RESULTS: Significantly lower expression of PAR-1 and higher expression of mast cell tryptase was detected in the colons of patients, with statistically unchanged expression of PAR-2.

Regulation (detected) of Gene_expression (expression) of tryptase in colons

2) Confidence 0.02 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19430717 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.