INT160049

Context Info Confidence 0.41 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.60 Pain Relevance 0.42

cytoplasm (PTEN, INPPL1) cytosol (PTEN, INPPL1) plasma membrane (PTEN, INPPL1) phosphatase activity (INPPL1) Golgi apparatus (INPPL1) enzyme binding (PTEN)

PTEN (Homo sapiens) INPPL1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 6 96.60

Disease Link Frequency Relevance Heat Reprotox - General 1 1 98.72 Cancer 4 93.52 Disease 1 87.16 INFLAMMATION 2 84.32 Targeted Disruption 1 42.24 Colon Cancer 1 37.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The prostate cancer cell line LNCaP, lacking both critical enzymes in the negative control of PKB/Akt activation, PTEN and SHIP2, was the most sensitive to these effects, as assessed by analysing the cell cycle profile and expression of cell cycle regulating proteins.

PTEN Regulation (control) of Gene_expression (activation) of SHIP2 associated with reprotox - general 1

1) Confidence 0.41 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.60 Pain Relevance 0.42

General Comments

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