INT160054

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Context Info
Confidence 0.73
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.93
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AKT2) transport (AKT2) mitochondrion (AKT2)
carbohydrate metabolic process (AKT2) cytoplasm (AKT2) cytosol (AKT2)
AKT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 14 90.44 High High
aspirin 7 84.20 Quite High
metalloproteinase 1 40.16 Quite Low
antagonist 4 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 6 96.36 Very High Very High Very High
Injury 1 95.80 Very High Very High Very High
Targeted Disruption 5 88.80 High High
Colon Cancer 5 81.04 Quite High
Reprotox - General 1 2 75.48 Quite High
Cancer 21 75.00 Quite High
INFLAMMATION 5 75.00 Quite High
Disease 3 65.20 Quite High
Hypertrophy 1 37.68 Quite Low
Body Weight 7 23.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
/Akt2 protein (but not mRNA) suggests increased translation of PKB?
Localization (translation) of Akt2
1) Confidence 0.73 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0 Pain Relevance 0
Interestingly, we also found that indomethacin activated PKB/Akt and induced nuclear localisation of p21(Cip1/Waf1) and Akt2 isoform.
Localization (localisation) of Akt2
2) Confidence 0.67 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.72 Pain Relevance 0.44
Interestingly, we also found that indomethacin activated PKB/Akt and induced nuclear localisation of p21(Cip1/Waf1) and Akt2 isoform.
Localization (localisation) of Akt2
3) Confidence 0.67 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.72 Pain Relevance 0.44
As AKT2 and AKT3 are closely related and highly conserved homologs of AKT1, whether AKT2 and AKT3 are targets of Wnt/?
Localization (targets) of AKT2
4) Confidence 0.34 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.48 Pain Relevance 0.31

General Comments

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