INT160055

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 12.56
Pain Relevance 4.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1A) nucleoplasm (CDKN1A) nucleus (CDKN1A)
cell cycle (CDKN1A) kinase activity (CDKN1A) cytoplasm (CDKN1A)
Anatomy Link Frequency
telomere 2
HGF 1
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 292 95.28 Very High Very High Very High
Osteoarthritis 90 94.88 High High
Inflammation 12 91.68 High High
cINOD 54 90.44 High High
local anesthetic 1 14.64 Low Low
Dopamine 1 10.72 Low Low
Central nervous system 10 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 104 98.56 Very High Very High Very High
Targeted Disruption 21 97.60 Very High Very High Very High
Aging 56 97.56 Very High Very High Very High
Cyst 63 97.44 Very High Very High Very High
Disease 113 96.36 Very High Very High Very High
Osteoarthritis 90 94.88 High High
Colon Cancer 9 92.96 High High
INFLAMMATION 30 91.68 High High
Stress 38 91.32 High High
Hyperoxia 1 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When p21 is phosphorylated by upstream molecules such as phosphorylated Akt, p21 is translocated into the cytosol to act as an anti-apoptotic protein.
Localization (translocated) of p21 associated with apoptosis
1) Confidence 0.78 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 1.21 Pain Relevance 0
Interestingly, we also found that indomethacin activated PKB/Akt and induced nuclear localisation of p21(Cip1/Waf1) and Akt2 isoform.
Localization (localisation) of p21
2) Confidence 0.78 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.72 Pain Relevance 0.43
Interestingly, we also found that indomethacin activated PKB/Akt and induced nuclear localisation of p21(Cip1/Waf1) and Akt2 isoform.
Localization (localisation) of Waf1
3) Confidence 0.78 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.72 Pain Relevance 0.43
Interestingly, we also found that indomethacin activated PKB/Akt and induced nuclear localisation of p21(Cip1/Waf1) and Akt2 isoform.
Localization (localisation) of Cip1
4) Confidence 0.78 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.72 Pain Relevance 0.43
While this data is consistent with our finding that p21 is decreased in cystic tissue, whether HGF lies within the polycystin 1 ?
Localization (decreased) of p21 in HGF
5) Confidence 0.73 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.33 Pain Relevance 0
Our results are in agreement with other studies and suggest that maintaining of the p21(Cip1/Waf1) level and its intracellular localisation might be influenced by Akt2.
Localization (localisation) of Cip1
6) Confidence 0.73 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.73 Pain Relevance 0.43
Indeed, in vitro treatment of chondrocytes with oxygen peroxide (H2O2) used as source of ROS, resulted in p53/p21Waf1/Cip1, p16ink4a accumulation and telomere attrition which are both hallmarks of cellular senescence [12, 28, 29].
Localization (accumulation) of Cip1 in telomere associated with aging
7) Confidence 0.73 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.41 Pain Relevance 0.28
Our results are in agreement with other studies and suggest that maintaining of the p21(Cip1/Waf1) level and its intracellular localisation might be influenced by Akt2.
Localization (localisation) of Waf1
8) Confidence 0.73 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.73 Pain Relevance 0.42
Our results are in agreement with other studies and suggest that maintaining of the p21(Cip1/Waf1) level and its intracellular localisation might be influenced by Akt2.
Localization (localisation) of p21
9) Confidence 0.73 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.73 Pain Relevance 0.43
Indeed, in vitro treatment of chondrocytes with oxygen peroxide (H2O2) used as source of ROS, resulted in p53/p21Waf1/Cip1, p16ink4a accumulation and telomere attrition which are both hallmarks of cellular senescence [12, 28, 29].
Localization (resulted) of Cip1 in telomere associated with aging
10) Confidence 0.73 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.42 Pain Relevance 0.28
When p21 is phosphorylated by upstream molecules such as phosphorylated Akt, p21 is translocated into the cytosol to act as an anti-apoptotic protein.
Localization (translocated) of p21 associated with apoptosis
11) Confidence 0.68 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 1.30 Pain Relevance 0
Interestingly, we also found that indomethacin activated PKB/Akt and induced nuclear localisation of p21(Cip1/Waf1) and Akt2 isoform.
Localization (localisation) of Waf1
12) Confidence 0.68 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.72 Pain Relevance 0.43
Interestingly, we also found that indomethacin activated PKB/Akt and induced nuclear localisation of p21(Cip1/Waf1) and Akt2 isoform.
Localization (localisation) of Cip1
13) Confidence 0.68 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.72 Pain Relevance 0.43
Interestingly, we also found that indomethacin activated PKB/Akt and induced nuclear localisation of p21(Cip1/Waf1) and Akt2 isoform.
Localization (localisation) of p21
14) Confidence 0.68 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.72 Pain Relevance 0.43
The primers used were: for the human p21Cip1 promoter containing the VDRE (located at ?
Localization (located) of p21Cip1
15) Confidence 0.62 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.06 Pain Relevance 0
M for 7 d) cell proliferation inhibition has been suggested to be related to increased expression of p21, a major transcriptional target of p53, as well as down-regulation of nuclear antigen (PCNA), an essential DNA replication factor [11].
Localization (target) of p21
16) Confidence 0.09 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.31 Pain Relevance 0.40

General Comments

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