INT160056

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.43
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AKT2) transport (AKT2) mitochondrion (AKT2)
carbohydrate metabolic process (AKT2) cytoplasm (AKT2) cytosol (AKT2)
Anatomy Link Frequency
epithelial cells 1
dorsal horns 1
AKT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 14 100.00 Very High Very High Very High
cINOD 6 98.80 Very High Very High Very High
Inflammation 17 94.24 High High
withdrawal 7 80.68 Quite High
allodynia 2 74.36 Quite High
Brush evoked pain 20 68.08 Quite High
Kinase C 1 67.72 Quite High
Spinal cord 11 55.76 Quite High
cytokine 14 52.52 Quite High
cerebral cortex 1 51.84 Quite High
Disease Link Frequency Relevance Heat
Cancer 6 99.50 Very High Very High Very High
Brain Hemorrhage 1 97.76 Very High Very High Very High
Vasculitis 1 94.60 High High
Myocardial Infarction 1 93.24 High High
Colon Cancer 1 92.32 High High
Cv Unclassified Under Development 1 91.88 High High
Reperfusion Injury 1 91.48 High High
Targeted Disruption 2 89.72 High High
Apoptosis 2 88.20 High High
INFLAMMATION 21 77.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggest novel mechanisms of NSAIDs antiproliferative action in cancer epithelial cells, which depends on the status of negative regulation of the PKB/Akt pathway and the isoform-specific action of Akt2.
Positive_regulation (depends) of Akt2 in epithelial cells associated with cancer and cinod
1) Confidence 0.48 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.54 Pain Relevance 0.30
in the dorsal horns of vehicle-treated rats remained at low levels, but was markedly increased 30 min after intrathecal PDGF-BB (10 pmol) administration (P < 0.001) (Figure 2A, B).
Positive_regulation (increased) of -BB in dorsal horns associated with intrathecal
2) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.20 Pain Relevance 0.43
Similarly, binding of glucocorticoids to the GR-stimulated phosphatidylinositol 3-kinase and protein kinase Akt, leading to endothelial NOS activation and nitric oxide dependent vasorelaxation, is the mechanism by which glucocorticoids decreased vascular inflammation and reduced myocardial infarct size following ischaemia/reperfusion injury in mice [103].



Positive_regulation (stimulated) of protein kinase Akt associated with reperfusion injury, inflammation, cv unclassified under development, vasculitis and myocardial infarction
3) Confidence 0.04 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.69 Pain Relevance 0.15

General Comments

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