INT160056

Context Info Confidence 0.48 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.43 Pain Relevance 0.88

nucleoplasm (AKT2) transport (AKT2) mitochondrion (AKT2) carbohydrate metabolic process (AKT2) cytoplasm (AKT2) cytosol (AKT2)

Anatomy Link Frequency epithelial cells 1 dorsal horns 1 AKT2 (Homo sapiens)

Pain Link Frequency Relevance Heat intrathecal 14 100.00 cINOD 6 98.80 Inflammation 17 94.24 withdrawal 7 80.68 allodynia 2 74.36 Brush evoked pain 20 68.08 Kinase C 1 67.72 Spinal cord 11 55.76 cytokine 14 52.52 cerebral cortex 1 51.84

Disease Link Frequency Relevance Heat Cancer 6 99.50 Brain Hemorrhage 1 97.76 Vasculitis 1 94.60 Myocardial Infarction 1 93.24 Colon Cancer 1 92.32 Cv Unclassified Under Development 1 91.88 Reperfusion Injury 1 91.48 Targeted Disruption 2 89.72 Apoptosis 2 88.20 INFLAMMATION 21 77.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our data suggest novel mechanisms of NSAIDs antiproliferative action in cancer epithelial cells, which depends on the status of negative regulation of the PKB/Akt pathway and the isoform-specific action of Akt2.

Positive_regulation (depends) of Akt2 in epithelial cells associated with cancer and cinod

1) Confidence 0.48 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.54 Pain Relevance 0.30

in the dorsal horns of vehicle-treated rats remained at low levels, but was markedly increased 30 min after intrathecal PDGF-BB (10 pmol) administration (P < 0.001) (Figure 2A, B).

Positive_regulation (increased) of -BB in dorsal horns associated with intrathecal

2) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.20 Pain Relevance 0.43

Similarly, binding of glucocorticoids to the GR-stimulated phosphatidylinositol 3-kinase and protein kinase Akt, leading to endothelial NOS activation and nitric oxide dependent vasorelaxation, is the mechanism by which glucocorticoids decreased vascular inflammation and reduced myocardial infarct size following ischaemia/reperfusion injury in mice [103].

Positive_regulation (stimulated) of protein kinase Akt associated with reperfusion injury, inflammation, cv unclassified under development, vasculitis and myocardial infarction

3) Confidence 0.04 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.69 Pain Relevance 0.15

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