INT160070

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.54
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ERAP2) endoplasmic reticulum (ERAP2)
ERAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 6 99.00 Very High Very High Very High
Inflammation 12 65.28 Quite High
Inflammatory response 4 24.16 Low Low
Disease Link Frequency Relevance Heat
Eclampsia 24 99.60 Very High Very High Very High
Low Back Pain 6 99.00 Very High Very High Very High
Malaria 16 92.24 High High
Infection 4 91.84 High High
Hepatitis 4 91.12 High High
Cancer 12 85.36 High High
INFLAMMATION 16 65.28 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 16 22.64 Low Low
Targeted Disruption 24 20.44 Low Low
Reprotox - General 1 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, based on our results, the ERAP2 genotype should be accounted for in interpreting ERAP2 studies, especially those focused on ERAP2 expression and ERAP2 protein function.
ERAP2 Binding (interpreting) of
1) Confidence 0.37 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.09 Pain Relevance 0
Interestingly, a recent study revealed an association between the ERAP2 Haplotype A and pre-eclampsia in an Australian cohort [34].
ERAP2 Binding (association) of associated with eclampsia
2) Confidence 0.37 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.78 Pain Relevance 0
It is worth noting that LD between ERAP1 and ERAP2 is low (Figure S9), and the two most common ERAP1 haplotypes do not show linkage with the two major ERAP2 haplotypes (data not shown), indicating that the ERAP1 signatures are independent from those of ERAP2.
ERAP2 Neg (not) Binding (linkage) of
3) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
This has been proposed for FLT1, a gene that, like ERAP2, is associated with pre-eclampsia [70].
ERAP2 Binding (associated) of associated with eclampsia
4) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.58 Pain Relevance 0.03
Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis.
ERAP2 Binding (Association) of associated with spinal inflammation
5) Confidence 0.21 Published 2010 Journal Ann. Rheum. Dis. Section Title Doc Link 19433412 Disease Relevance 0.10 Pain Relevance 0.19

General Comments

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