INT160080

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.86
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Ecm1) signal transducer activity (Ecm1) extracellular space (Ecm1)
signal transduction (Ecm1) extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1)
Anatomy Link Frequency
extracellular matrix 2
cartilage 1
cavity 1
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 69 100.00 Very High Very High Very High
Arthritis 30 99.30 Very High Very High Very High
cytokine 23 98.68 Very High Very High Very High
Osteoarthritis 76 98.12 Very High Very High Very High
fibrosis 11 97.64 Very High Very High Very High
metalloproteinase 75 92.96 High High
Chronic pancreatitis 6 84.56 Quite High
chemokine 8 49.16 Quite Low
Deafferentation 2 13.52 Low Low
Hippocampus 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 70 100.00 Very High Very High Very High
Arthritis 30 99.30 Very High Very High Very High
Synovitis 2 98.34 Very High Very High Very High
Osteoarthritis 78 98.12 Very High Very High Very High
Fibrosis 12 97.64 Very High Very High Very High
Disease 6 87.92 High High
Adhesions 4 86.64 High High
Hyperplasia 7 86.40 High High
Genetic Predisposition To Disease 2 84.92 Quite High
Pancreatitis 8 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, Annexin IV and other annexins can act as ligands for proteoglycans localized on the cell surface, in the ECM, or in secretory granules [24,25].
Localization (localized) of ECM
1) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.03
The extracellular matrix protein SPARC (secreted protein, acidic, and rich in cysteines) and other transcripts of inflammatory genes were quantified by real-time PCR, and some were localized by immunohistochemistry.
Localization (secreted) of extracellular matrix protein in extracellular matrix associated with inflammation
2) Confidence 0.10 Published 2009 Journal Physiol. Genomics Section Abstract Doc Link 19435834 Disease Relevance 1.04 Pain Relevance 0.57
The extracellular matrix protein SPARC (secreted protein, acidic, and rich in cysteines) and other transcripts of inflammatory genes were quantified by real-time PCR, and some were localized by immunohistochemistry.
Localization (localized) of extracellular matrix protein in extracellular matrix associated with inflammation
3) Confidence 0.09 Published 2009 Journal Physiol. Genomics Section Abstract Doc Link 19435834 Disease Relevance 1.16 Pain Relevance 0.62
OPN, a secreted phosphoprotein, exists both as an immobilized ECM molecule in mineralized tissues and as a cytokine that mediates cellular functions involved in inflammation and ECM remodelling [31].
Localization (molecule) of ECM associated with inflammation and cytokine
4) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.66 Pain Relevance 0.29
The ECM is composed of secreted glycoproteins and
Localization (secreted) of ECM
5) Confidence 0.08 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838960 Disease Relevance 0.30 Pain Relevance 0.09
In the monoiodoacetic acid-induced arthritis model, anti-FGF8 antibody reduced ECM release into the synovial cavity.
Localization (release) of ECM in cavity associated with arthritis
6) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575604 Disease Relevance 0.58 Pain Relevance 0.33
In OA, synovitis is believed to be a reactive process as a result of cartilage destruction and the release of ECM-degradation products in the synovial fluid [1].
Localization (release) of ECM-degradation in cartilage associated with synovitis and osteoarthritis
7) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 1.12 Pain Relevance 0.42

General Comments

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