INT160083

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Context Info
Confidence 0.16
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.53
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (TGFB1, L1CAM) cell differentiation (L1CAM) aging (TGFB1)
enzyme binding (TGFB1) embryo development (TGFB1) cytoplasm (TGFB1)
Anatomy Link Frequency
pancreatic duct 2
TGFB1 (Homo sapiens)
L1CAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 88.12 High High
Disease Link Frequency Relevance Heat
Fibrosis 2 92.08 High High
Pancreatitis 2 88.12 High High
Adenocarcinoma 14 85.20 High High
Malignant Neoplastic Disease 6 83.16 Quite High
Pancreatic Cancer 2 75.00 Quite High
Adhesions 2 74.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the human pancreatic duct cell line H6c7, we show that coculture with PMFs led to a transforming growth factor-beta1 (TGF-beta1)-dependent up-regulation of L1CAM expression.
TGF-beta1 Positive_regulation (up-regulation) of Gene_expression (expression) of L1CAM in pancreatic duct
1) Confidence 0.16 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.85 Pain Relevance 0.09
Moreover, Slug interacted with the L1CAM promoter, and its knockdown abrogated the TGF-beta1- and PMF-induced L1CAM expression.
TGF-beta1 Positive_regulation (induced) of Gene_expression (expression) of L1CAM
2) Confidence 0.16 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.68 Pain Relevance 0.07

General Comments

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