INT160084

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Context Info
Confidence 0.78
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 18
Disease Relevance 10.92
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (L1CAM) cell death (L1CAM) cell adhesion (L1CAM)
plasma membrane (L1CAM)
Anatomy Link Frequency
skin 2
pancreatic duct 2
L1CAM (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 48 100.00 Very High Very High Very High
Chronic pancreatitis 13 99.34 Very High Very High Very High
Nerve growth factor 24 59.08 Quite High
Root ganglion neuron 4 38.84 Quite Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
fifth nerve 4 5.00 Very Low Very Low Very Low
neurotrophin 3 4 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 33 100.00 Very High Very High Very High
Adenocarcinoma 91 99.80 Very High Very High Very High
Fibrosis 13 99.60 Very High Very High Very High
Pancreatitis 13 99.34 Very High Very High Very High
Malignant Neoplastic Disease 43 98.88 Very High Very High Very High
Cervical Cancer 2 78.24 Quite High
Pancreatic Cancer 13 75.00 Quite High
Adenoid Cystic Carcinoma 42 50.00 Quite Low
Ganglion Cysts 4 38.52 Quite Low
Nervous System Injury 4 32.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry of tissues from chronic pancreatitis specimens revealed considerable L1CAM expression in ductal structures surrounded by dense fibrotic tissue, whereas no L1CAM staining was seen in normal pancreatic tissues.
Gene_expression (expression) of L1CAM associated with fibrosis and chronic pancreatitis
1) Confidence 0.78 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.94 Pain Relevance 0.10
Previously, we observed high expression of the adhesion molecule L1CAM (CD171) in PDAC cells accounting for chemoresistance.
Gene_expression (expression) of L1CAM associated with adenocarcinoma and adhesions
2) Confidence 0.78 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.94 Pain Relevance 0.08
Both TGF-beta1- and PMF-induced L1CAM expression were independent of Smad proteins but required c-Jun NH(2)-terminal kinase activation leading to the induction of the transcription factor Slug.
Gene_expression (expression) of L1CAM
3) Confidence 0.78 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.84 Pain Relevance 0.08
As a result of L1CAM expression, H6c7 cells acquired a chemoresistant and migratory phenotype.
Gene_expression (expression) of L1CAM
4) Confidence 0.78 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.67 Pain Relevance 0.07
Similarly, L1CAM expression increased in monocultured H6c7 cells after administration of exogenous TGF-beta1.
Gene_expression (expression) of L1CAM
5) Confidence 0.78 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.83 Pain Relevance 0.09
Using the human pancreatic duct cell line H6c7, we show that coculture with PMFs led to a transforming growth factor-beta1 (TGF-beta1)-dependent up-regulation of L1CAM expression.
Gene_expression (expression) of L1CAM in pancreatic duct
6) Confidence 0.78 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.84 Pain Relevance 0.09
Moreover, Slug interacted with the L1CAM promoter, and its knockdown abrogated the TGF-beta1- and PMF-induced L1CAM expression.
Gene_expression (expression) of L1CAM
7) Confidence 0.78 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.67 Pain Relevance 0.07
This mechanism of TGF-beta1-induced L1CAM expression and the resulting phenotype could be verified in the TGF-beta1-responsive PDAC cell lines Colo357 and Panc1.
Gene_expression (expression) of L1CAM associated with adenocarcinoma
8) Confidence 0.78 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.60 Pain Relevance 0.06
Previously, we observed high expression of the adhesion molecule L1CAM (CD171) in PDAC cells accounting for chemoresistance.
Gene_expression (expression) of CD171 associated with adenocarcinoma and adhesions
9) Confidence 0.75 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.94 Pain Relevance 0.08
Immunohistochemistry of tissues from chronic pancreatitis specimens revealed considerable L1CAM expression in ductal structures surrounded by dense fibrotic tissue, whereas no L1CAM staining was seen in normal pancreatic tissues.
Neg (no) Gene_expression (staining) of L1CAM associated with fibrosis and chronic pancreatitis
10) Confidence 0.67 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.92 Pain Relevance 0.10
Our data provide new insights into the mechanisms of tumoral L1CAM induction and how PMFs contribute to malignant transformation of pancreatic duct cells early in PDAC tumorigenesis.
Gene_expression (induction) of L1CAM in pancreatic duct associated with adenocarcinoma and malignant neoplastic disease
11) Confidence 0.67 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.66 Pain Relevance 0.06
Previously, we observed high expression of the adhesion molecule L1CAM (CD171) in PDAC cells accounting for chemoresistance.
Gene_expression (expression) of L1CAM associated with adenocarcinoma and adhesions
12) Confidence 0.67 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.94 Pain Relevance 0.08
Previously, we observed high expression of the adhesion molecule L1CAM (CD171) in PDAC cells accounting for chemoresistance.
Gene_expression (adhesion) of CD171 associated with adenocarcinoma and adhesions
13) Confidence 0.65 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.94 Pain Relevance 0.08
In fact, while frontal skin showed significant overexpression of BDNF, BMP2, L1-CAM, Meteorin and NR-CAM and significant underexpression of Midkine respect to the velvet, significant gene expression differences between pedicle skin and velvet were restricted to FGF2 and NR-CAM.
Gene_expression (overexpression) of L1-CAM in skin associated with bdmf
14) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0.14
Real time PCR data showed detectable gene expression (cycle threshold -Ct- below 34/35 cycles) for BDNF, BMP2, FGF2, GPI, L1CAM, Laminin B1 (LAMB1), Meteorin, Midkine, NR-CAM, and TGF?
Gene_expression (expression) of L1CAM associated with bdmf
15) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0.13
Real time PCR analysis also indicated the expression of GDNF, L1-CAM or LAMB1, but we could not sequence their PCR products, lacking the necessary identity confirmation.
Gene_expression (expression) of L1-CAM
16) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0.12 Pain Relevance 0.03
In fact, while frontal skin showed significant overexpression of BDNF, BMP2, L1-CAM, Meteorin and NR-CAM and significant underexpression of Midkine respect to the velvet, significant gene expression differences between pedicle skin and velvet were restricted to FGF2 and NR-CAM.
Gene_expression (underexpression) of L1-CAM in skin associated with bdmf
17) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0.11
Our STR analysis demonstrated that our ACC2, ACC3, and ACCM cells had nearly identical electrophoretic profiles (Table 1, and Figures 1 and S1, S2, S3, S4, S5, S6, S7, S8, S9, S10).
Gene_expression (had) of S10
18) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698276 Disease Relevance 0.08 Pain Relevance 0

General Comments

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