INT160087

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Context Info
Confidence 0.70
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 2.54
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (L1CAM) cell death (L1CAM) cell adhesion (L1CAM)
plasma membrane (L1CAM)
Anatomy Link Frequency
pancreatic duct 2
L1CAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 3 88.32 High High
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 9 98.88 Very High Very High Very High
Adenocarcinoma 21 96.52 Very High Very High Very High
Pancreatic Cancer 3 95.24 Very High Very High Very High
Adhesions 3 94.36 High High
Pancreatitis 3 88.32 High High
Fibrosis 3 79.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, this study aimed to investigate whether PMFs are involved in the induction of tumoral L1CAM and whether this contributes to malignant transformation of pancreatic ductal cells and PDAC tumorigenesis.
Spec (whether) Positive_regulation (induction) of L1CAM associated with adenocarcinoma and malignant neoplastic disease
1) Confidence 0.70 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.96 Pain Relevance 0.09
Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer.
Positive_regulation (Up-regulation) of L1CAM in pancreatic duct associated with malignant neoplastic disease and pancreatic cancer
2) Confidence 0.47 Published 2009 Journal Cancer Res. Section Title Doc Link 19435915 Disease Relevance 0.92 Pain Relevance 0.07
Our data provide new insights into the mechanisms of tumoral L1CAM induction and how PMFs contribute to malignant transformation of pancreatic duct cells early in PDAC tumorigenesis.
Positive_regulation (induction) of L1CAM in pancreatic duct associated with adenocarcinoma and malignant neoplastic disease
3) Confidence 0.47 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.66 Pain Relevance 0.06

General Comments

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