INT160088

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Context Info
Confidence 0.70
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.95
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (L1CAM) cell death (L1CAM) cell adhesion (L1CAM)
plasma membrane (L1CAM)
Anatomy Link Frequency
skin 2
L1CAM (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 12 100.00 Very High Very High Very High
Chronic pancreatitis 6 85.44 High High
Nerve growth factor 6 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
fifth nerve 1 5.00 Very Low Very Low Very Low
neurotrophin 3 1 5.00 Very Low Very Low Very Low
Root ganglion neuron 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 11 100.00 Very High Very High Very High
Adenocarcinoma 42 99.80 Very High Very High Very High
Fibrosis 6 89.40 High High
Malignant Neoplastic Disease 18 85.76 High High
Pancreatitis 6 85.44 High High
Pancreatic Cancer 6 75.00 Quite High
Body Weight 1 5.00 Very Low Very Low Very Low
Ganglion Cysts 1 5.00 Very Low Very Low Very Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both TGF-beta1- and PMF-induced L1CAM expression were independent of Smad proteins but required c-Jun NH(2)-terminal kinase activation leading to the induction of the transcription factor Slug.
Positive_regulation (induced) of Gene_expression (expression) of L1CAM
1) Confidence 0.70 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.84 Pain Relevance 0.08
Similarly, L1CAM expression increased in monocultured H6c7 cells after administration of exogenous TGF-beta1.
Positive_regulation (increased) of Gene_expression (expression) of L1CAM
2) Confidence 0.70 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.88 Pain Relevance 0.09
In fact, while frontal skin showed significant overexpression of BDNF, BMP2, L1-CAM, Meteorin and NR-CAM and significant underexpression of Midkine respect to the velvet, significant gene expression differences between pedicle skin and velvet were restricted to FGF2 and NR-CAM.
Positive_regulation (overexpression) of Gene_expression (overexpression) of L1-CAM in skin associated with bdmf
3) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0.14
Previously, we observed high expression of the adhesion molecule L1CAM (CD171) in PDAC cells accounting for chemoresistance.
Positive_regulation (high) of Gene_expression (expression) of L1CAM associated with adenocarcinoma and adhesions
4) Confidence 0.50 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.94 Pain Relevance 0.08
Moreover, Slug interacted with the L1CAM promoter, and its knockdown abrogated the TGF-beta1- and PMF-induced L1CAM expression.
Positive_regulation (induced) of Gene_expression (expression) of L1CAM
5) Confidence 0.50 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.67 Pain Relevance 0.07
Previously, we observed high expression of the adhesion molecule L1CAM (CD171) in PDAC cells accounting for chemoresistance.
Positive_regulation (high) of Gene_expression (expression) of CD171 associated with adenocarcinoma and adhesions
6) Confidence 0.49 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.94 Pain Relevance 0.08
As a result of L1CAM expression, H6c7 cells acquired a chemoresistant and migratory phenotype.
Positive_regulation (result) of Gene_expression (expression) of L1CAM
7) Confidence 0.47 Published 2009 Journal Cancer Res. Section Abstract Doc Link 19435915 Disease Relevance 0.67 Pain Relevance 0.07

General Comments

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