INT160093

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 5.44
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (C7)
Anatomy Link Frequency
vesicles 2
hepatocytes 1
muscle 1
ulnar nerve 1
lateral cord 1
C7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatica 100 100.00 Very High Very High Very High
Spinothalamic tract neurons 12 98.28 Very High Very High Very High
spinothalamic 111 97.60 Very High Very High Very High
Inflammation 48 94.44 High High
stellate ganglion block 3 91.92 High High
Spinal cord 375 90.12 High High
Dorsal horn 81 88.40 High High
cytokine 24 87.12 High High
Central nervous system 174 76.32 Quite High
Kinase C 24 75.36 Quite High
Disease Link Frequency Relevance Heat
Nerve Root Compression 123 100.00 Very High Very High Very High
Congenital Anomalies 6 99.96 Very High Very High Very High
Syndrome 4 99.56 Very High Very High Very High
INFLAMMATION 48 94.44 High High
Brachial Plexus Neuropathies 13 94.08 High High
Ganglion Cysts 8 91.68 High High
Confusion 3 91.52 High High
Nervous System Injury 3 90.64 High High
Spinal Cord Injury 420 90.60 High High
Injury 342 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This technique involves withdrawing the needle to locate its port for injection above the anterior surface of the LC muscle; however, its exact thickness at the C5, C6, and C7 levels has not been measured.
Gene_expression (levels) of C7 in anterior surface
1) Confidence 0.67 Published 2009 Journal Reg Anesth Pain Med Section Abstract Doc Link 19436184 Disease Relevance 0.17 Pain Relevance 0.25
When both C7 and C8 were avulsed, Horner's syndrome was more prone to be produced in pups than in adults (chi(2)=4.2, P=0.04).
Gene_expression (avulsed) of C7 associated with syndrome
2) Confidence 0.58 Published 2010 Journal Auton Neurosci Section Abstract Doc Link 20153267 Disease Relevance 0.65 Pain Relevance 0
Expression of C1q, C3, C4, C5, C6, C7, C9, CD59, Crry, and GADPH mRNAs in cultured PMNs was assayed by rt-PCR.
Gene_expression (Expression) of C7
3) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0 Pain Relevance 0
The lack of terminal complement mRNAs in cultured PMNs may not have been unexpected because several studies have suggested that C6 and C7 are not actively synthesized by PMNs in culture, but were likely presynthesized in PMNs during differentiation in the bone marrow, stored in cytoplasmic vesicles, and subsequently released during circulation [18,34].
Neg (not) Gene_expression (synthesized) of C7 in vesicles
4) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0 Pain Relevance 0.03
As shown in Figure 3 by rt-PCR, both unstimulated PMNs and stimulated PMNs expressed mRNAs encoding for C1q, C3, and C4, but not C6, C7, and C9 in culture.
Gene_expression (expressed) of C7
5) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.05 Pain Relevance 0.19
Because the length of C7 was 2.3 mm, whereas that of L4 is ?
Gene_expression (length) of C7
6) Confidence 0.31 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2658017 Disease Relevance 0.06 Pain Relevance 0.34
When data from these experiments were pooled, it was found that 255 out of 294 (87%) of the cells in C7 and 65 out of 77 (84%) of those in L4 were NK1r immunoreactive (Fig. 8).
Gene_expression (immunoreactive) of C7
7) Confidence 0.31 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2658017 Disease Relevance 0 Pain Relevance 0.05
The width of lamina I in the C7 segment (as judged by darkfield microscopy) was somewhat greater in the central region (up to 35 ?
Gene_expression (segment) of C7 in lamina
8) Confidence 0.31 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2658017 Disease Relevance 0.07 Pain Relevance 0.08
The lack of terminal complement mRNAs in cultured PMNs may not have been unexpected because several studies have suggested that C6 and C7 are not actively synthesized by PMNs in culture, but were likely presynthesized in PMNs during differentiation in the bone marrow, stored in cytoplasmic vesicles, and subsequently released during circulation [18,34].
Neg (not) Gene_expression (synthesized) of C7 in vesicles
9) Confidence 0.28 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0 Pain Relevance 0.03
For example, a previous study has suggested that although hepatocytes synthesize the majority of proteins of the complement system, most C7 proteins generated after liver transplantation are synthesized by other cell types [20], suggesting a local delivery of complement proteins and the contribution of complement-mediated events by a non-hepatocytic cellular source at the site of inflammation.
Gene_expression (synthesized) of C7 in hepatocytes associated with inflammation
10) Confidence 0.25 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.92 Pain Relevance 0.21
Stimulated or unstimulated PMNs expressed mRNAs encoding for C1q, C3, and C4, but not C5, C6, C7 or C9 in culture.
Gene_expression (expressed) of C7 in PMNs
11) Confidence 0.25 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2443364 Disease Relevance 1.33 Pain Relevance 0.37
However, many clinicians believe the C7 root to be present in the ulnar nerve, and abnormal findings could be observed in muscles innervated by the ulnar nerve, especially the flexor carpi ulnaris (FCU), in C7 radiculopathy (4-7).
Gene_expression (present) of C7 in ulnar nerve associated with sciatica
12) Confidence 0.09 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826750 Disease Relevance 0.43 Pain Relevance 0.26
The C7 myotome in the FCU is relatively common, and needle EMG of this muscle may provide more information for the electrodiagnosis of cervical radiculopathy and brachial plexopathy.



Gene_expression (myotome) of C7 in muscle associated with brachial plexus neuropathies, nerve root compression and sciatica
13) Confidence 0.09 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826750 Disease Relevance 0.50 Pain Relevance 0.26
The medial cord is composed of the C8 and T1 sensory and motor fibers, but when the lateral cord or C7 root sends fibers to the ulnar nerve, C7 radiculopathy can produce abnormalities in muscles innervated by the ulnar nerve, such as the FCU.
Gene_expression (produce) of C7 in lateral cord associated with congenital anomalies and sciatica
14) Confidence 0.08 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826750 Disease Relevance 1.26 Pain Relevance 0.64

General Comments

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