INT160115

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.24
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
PSP 2
Fcer2a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 74 99.48 Very High Very High Very High
tolerance 12 99.40 Very High Very High Very High
Pain 1 98.04 Very High Very High Very High
Inflammation 59 64.00 Quite High
Nerve growth factor 11 5.00 Very Low Very Low Very Low
substance P 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 148 100.00 Very High Very High Very High
Eosinophilia 12 99.96 Very High Very High Very High
Disease 70 99.16 Very High Very High Very High
Pain 1 98.04 Very High Very High Very High
Vomiting 2 97.32 Very High Very High Very High
Diarrhoea 6 96.60 Very High Very High Very High
Immunization 19 92.24 High High
Sprains And Strains 84 85.04 High High
Asthma 73 80.16 Quite High
Measles 1 77.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dose-related effects of allergen exposure on IgE responses have been studied most extensively using cat allergen (Fel d 1).
Regulation (effects) of IgE
1) Confidence 0.11 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.12 Pain Relevance 0.05
The pattern of eosinophilia, IgE and MCh responsiveness in mice was determined by antigen dose at challenge.
Regulation (responsiveness) of IgE associated with eosinophilia
2) Confidence 0.09 Published 2004 Journal Respir Res Section Abstract Doc Link PMC521690 Disease Relevance 0.34 Pain Relevance 0.03
PG102 has previously been shown to control various factors involved in allergy pathogenesis, including IgE and various Th1 and Th2 cytokines, in vivo as well as in vitro [Park EJ, et al.: J Allergy Clin Immunol 2005;116:1151-1157; Park EJ, et al.: J Invest Dermatol 2007;127:1154-1160].
Regulation (control) of IgE associated with hypersensitivity and cytokine
3) Confidence 0.06 Published 2009 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 19439982 Disease Relevance 0.98 Pain Relevance 0.15
Interestingly, in some experiments performed in this and our other related studies evaluating how allergic mothers influence parameters of allergic disease in offspring, allergen-specific IgG1 and IgE responses were virtually absent without profound effects on airway eosinophilia.
Regulation (responses) of IgE associated with hypersensitivity, disease and eosinophilia
4) Confidence 0.02 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 1.09 Pain Relevance 0
Similar to the responses in NIH mice, PSP had an adjuvant effect on both IgE and IgG2a responses in C3H/HeN mice, although the responses appeared weaker in C3H/HeN than in NIH and BALB/c mice.
Regulation (responses) of IgE in PSP
5) Confidence 0.01 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.33 Pain Relevance 0.06
We examined how polystyrene particles (PSP) affected the IgE and IgG2a responses against the model allergen ovalbumin (OVA), after subcutaneous injection into the footpad of BALB/cA, BALB/cJ, NIH and C3H/HeN mice, Further, ex vivo IL-4, IFN-?
Spec (examined) Regulation (responses) of IgE in PSP
6) Confidence 0.01 Published 2005 Journal BMC Immunol Section Abstract Doc Link PMC1182367 Disease Relevance 0.38 Pain Relevance 0.08

General Comments

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