INT16012

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Context Info
Confidence 0.37
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 6.90
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Anatomy Link Frequency
endothelial cells 2
tube 1
Rac1 (Mus musculus)
Pain Link Frequency Relevance Heat
Botox 3 100.00 Very High Very High Very High
ischemia 10 94.52 High High
Action potential 1 81.84 Quite High
palliative 2 75.48 Quite High
Pain 9 68.08 Quite High
headache 7 53.32 Quite High
antiepileptic Drug 1 53.08 Quite High
lidocaine 2 50.00 Quite Low
Inflammation 25 5.00 Very Low Very Low Very Low
Crohn's disease 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Poisoning 3 99.96 Very High Very High Very High
Cramps 5 99.88 Very High Very High Very High
Mevalonate Kinase Deficiency 348 99.16 Very High Very High Very High
Movement Disorders 1 96.48 Very High Very High Very High
Botulism 58 95.52 Very High Very High Very High
Cv Unclassified Under Development 20 94.52 High High
Skin Appendage Disease 3 94.20 High High
Increased Venous Pressure Under Development 10 93.24 High High
Myasthenia Gravis 3 92.32 High High
Syndrome 20 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Writer's cramp: the experience with botulinum toxin injections in 25 patients.
botulinum toxin Binding (experience) of associated with cramps
1) Confidence 0.37 Published 1991 Journal J Med Assoc Thai Section Title Doc Link 1783871 Disease Relevance 0.71 Pain Relevance 0.09
Rac1 is not essential for VEGF-mediated endothelial cell proliferation, scratch closure or tube formation in 2-dimensions
Rac1 Binding (formation) of in tube
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
Oligonucleotides coding shRNA for mouse Rac1, mouse VEGFR2/Flk-1, ?
Rac1 Binding (coding) of
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
In addition, Rac1-deletion in Tie2-Cre mice has implied a role for Rac1 in developmental vasculogenesis, due, possibly, to its deletion both in Tie2-positive endothelial cells and in approximately 80% of hematopoetic cells which are also Tie2-positive [25].
Rac1 Binding (implied) of in endothelial cells
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.47 Pain Relevance 0.05
Regarding proliferation, our results corroborate the findings that increased Rac1 activity correlates with enhanced endothelial proliferation, since the elevated Rac1-activity in ?
Rac1 Binding (activity) of
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.31 Pain Relevance 0
In addition, Rac1-deletion in Tie2-Cre mice has implied a role for Rac1 in developmental vasculogenesis, due, possibly, to its deletion both in Tie2-positive endothelial cells and in approximately 80% of hematopoetic cells which are also Tie2-positive [25].
Rac1 Binding (role) of in endothelial cells
6) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.47 Pain Relevance 0.05
The intensity of pain associated with the botulinum toxin intracutaneous injections was self-assessed by the patients and was evaluated using a 100-mm visual analogue scale.
botulinum toxin Binding (associated) of
7) Confidence 0.35 Published 2007 Journal Br. J. Dermatol. Section Body Doc Link 17286630 Disease Relevance 0 Pain Relevance 0
However, since symptomatic improvement with botulinum toxin only lasts a few months, either repeated injections are required or the patient must be switched to other therapy.
botulinum toxin Binding (improvement) of
8) Confidence 0.30 Published 2001 Journal Dig Liver Dis Section Abstract Doc Link 11407673 Disease Relevance 0.32 Pain Relevance 0.08
Managing adverse events associated with botulinum toxin type A: a focus on cosmetic procedures.
botulinum toxin Binding (associated) of associated with botox
9) Confidence 0.26 Published 2005 Journal Am J Clin Dermatol Section Title Doc Link 15943491 Disease Relevance 0.54 Pain Relevance 0.23
To determine whether the observed increase of active GTP-bound RhoA and Rac1 during the different culturing conditions was due to activation of soluble or membrane-bound RhoA and Rac1, we studied separately the effect of simvastatin.
Rac1 Binding (bound) of
10) Confidence 0.24 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.50 Pain Relevance 0
Effect of simvastatin on activation of soluble and membrane-bound RhoA and Rac1
Rac1 Binding (bound) of
11) Confidence 0.24 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.44 Pain Relevance 0
Incubation with simvastatin led to an increase in the total levels of active, GTP-bound RhoA and Rac1 in both control and MKD cells.
Rac1 Binding (bound) of associated with mevalonate kinase deficiency
12) Confidence 0.24 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.24 Pain Relevance 0
To determine whether the observed increase of active GTP-bound RhoA and Rac1 during the different culturing conditions was due to activation of soluble or membrane-bound RhoA and Rac1, we studied separately the effect of simvastatin.
Rac1 Binding (bound) of
13) Confidence 0.24 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.53 Pain Relevance 0
Incubation with GGTI led to a reduction in membrane-bound RhoA and Rac1 that was similar for both control and MKD cells (Fig. 2b, g) and, in parallel, an increase in the levels of soluble RhoA and Rac1 (Fig. 2c and 2h).
Rac1 Binding (bound) of associated with mevalonate kinase deficiency
14) Confidence 0.24 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.30 Pain Relevance 0
Interestingly, E-cadherin has been shown to recruit Rac1 which in turn leads to stabilization of the anchoring of the E-cadherin-catenin complex to actin [38].
Rac1 Binding (recruit) of
15) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.13 Pain Relevance 0
Fig. 3Effect of simvastatin on activation of membrane-bound and soluble RhoA (a–c) and Rac1 (d–f).
Rac1 Binding (bound) of
16) Confidence 0.21 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.50 Pain Relevance 0
Characteristic electromyography (EMG) patterns have been described in association with botulinum toxin poisoning.
botulinum toxin Binding (association) of associated with poisoning
17) Confidence 0.01 Published 2009 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2791728 Disease Relevance 1.44 Pain Relevance 0.04

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