INT16013

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2010
Negated 3
Speculated 7
Reported most in Body
Documents 52
Total Number 66
Disease Relevance 23.79
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Anatomy Link Frequency
endothelial cells 7
bar 2
muscle 2
sweat 2
retina 1
Rac1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 73 100.00 Very High Very High Very High
Botox 32 100.00 Very High Very High Very High
antiepileptic Drug 1 93.36 High High
palliative 1 89.80 High High
Dopamine 4 87.64 High High
headache 14 86.20 High High
Pain 41 83.76 Quite High
Kinase C 1 81.20 Quite High
cINOD 47 79.60 Quite High
Calcium channel 1 73.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 124 100.00 Very High Very High Very High
Cancer 3232 99.84 Very High Very High Very High
Clostridium Infection 2 99.68 Very High Very High Very High
Targeted Disruption 237 99.14 Very High Very High Very High
Mevalonate Kinase Deficiency 754 99.04 Very High Very High Very High
Aids-related Complex 2 98.84 Very High Very High Very High
Progressive Bulbar Palsy 4 98.52 Very High Very High Very High
Parkinson's Disease 24 98.32 Very High Very High Very High
Botulism 58 98.24 Very High Very High Very High
Injury 131 98.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vania Braga, Imperial College, London, UK), was used to pull down active Rac1 and Cdc42 from MLEC cell lysates transfected with scrambled or Rac1 siRNA.
Gene_expression (transfected) of Rac1 siRNA
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
3-null mice were all dependent on endothelial Rac1 expression since Rac1-depletion in ?
Gene_expression (expression) of Rac1
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.80 Pain Relevance 0
Rac1 expression in transfected aortic rings was assessed by using both semiquantitative RT-PCR and Western blot analysis.


Gene_expression (expression) of Rac1
3) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.06 Pain Relevance 0
However, we report that active levels of Rac1 are increased in ?
Gene_expression (levels) of Rac1
4) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.77 Pain Relevance 0
3-null endothelial cells, since we have shown, that by inhibiting Rac1 expression alone, we can reduce the enhanced angiogenic responses of ?
Gene_expression (expression) of Rac1 in endothelial cells
5) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.18 Pain Relevance 0.06
These findings reveal that, unexpectedly, Rac1 expression in adult endothelial cells is not essential for tumor angiogenesis.
Gene_expression (expression) of Rac1 in endothelial cells associated with cancer
6) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.77 Pain Relevance 0
Taken together, these data indicate that, while no biological effect of Rac-1 knockdown was observed in wild-type/Tie1-Cre+, the lentivirus treatment efficiently reduced expression of Rac1 in tumor blood vessels from these animals.
Gene_expression (expression) of Rac1 in blood vessels associated with cancer
7) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.93 Pain Relevance 0
Taken together these data suggest that Rac1 expression in endothelial cells is not essential for VEGF-mediated angiogenesis in wild-type mice but is involved in such responses in ?
Gene_expression (expression) of Rac1 in endothelial cells
8) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
Twenty-one patients (84%) had botulinum toxin injections, 40-80 international mouse units were given in 2-4 divided doses over the overactive forearm muscles observed during writing without the electromyographic glidance.
Gene_expression (injections) of botulinum toxin in muscles
9) Confidence 0.67 Published 1991 Journal J Med Assoc Thai Section Abstract Doc Link 1783871 Disease Relevance 0.61 Pain Relevance 0.20
As expected, no significant changes in either mRNA or protein levels of Rac1 or Flk-1 were observed in pSico-Con infected cells (Figure 2B).
Gene_expression (levels) of Rac1
10) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.47 Pain Relevance 0
Importantly, tamoxifen treatment of non-endothelial cells isolated from Rac1 flox/flox PDGFB-iCreER mice had no effect on Rac1 expression (Figure 4A).
Gene_expression (expression) of Rac1 in endothelial cells
11) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.32 Pain Relevance 0
Using multiple in vivo approaches, we demonstrated that endothelial Rac1 is not essential for tumor growth or tumor angiogenesis in adult wild-type mice, but that these processes become Rac1-dependent in the absence of ?
Gene_expression (dependent) of Rac1 associated with cancer
12) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.34 Pain Relevance 0
3-integrin knockout endothelial cells without affecting total Rac1 levels, and that transduction of human ?
Gene_expression (levels) of Rac1 in endothelial cells associated with targeted disruption
13) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.76 Pain Relevance 0
3-null mice were transfected with either a scrambled control (Con) or Rac1-specific siRNA.
Gene_expression (transfected) of Rac1
14) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
These investigators showed that a dominant negative mutant of N-Ras (a small GTPase from a different family to that of Rac1) suppressed capillary-network formation of endothelial cells induced by VEGF-A-producing fibroblasts whereas the mutants of Rac1, RhoA or Cdc42 did not.
Gene_expression (producing) of Rac1 in endothelial cells
15) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.19 Pain Relevance 0.07
Deletion of Rac1 in the vascular endothelium did not affect tumor size or tumor angiogenesis when compared with controls (Figure 4B).
Gene_expression (Deletion) of Rac1 in vascular endothelium associated with cancer
16) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.36 Pain Relevance 0
To begin to understand the mechanisms responsible for the biological effects of Rac1-depletion in wild-type and ?
Gene_expression (effects) of Rac1-depletion
17) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
This suggested that the elevated Rac1 activity that occurs in ?
Gene_expression (activity) of Rac1
18) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
Vania Braga, Imperial College, London, UK), was used to pull down active Rac1 and Cdc42 from MLEC cell lysates transfected with scrambled or Rac1 siRNA.
Gene_expression (transfected) of Rac1
19) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
We provide evidence that Rac1 activity (Rac1-GTP) is elevated in ?
Gene_expression (activity) of Rac1
20) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.76 Pain Relevance 0

General Comments

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