INT160141

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.17
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
plasma 1
neurons 1
IB4 1
Cxcl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 7 96.20 Very High Very High Very High
Inflammation 65 94.96 High High
cytokine 32 93.92 High High
Spinal cord 7 91.76 High High
nav1.8 3 84.56 Quite High
Nav1.9 9 73.76 Quite High
Peripheral nervous system 11 70.76 Quite High
Central nervous system 7 63.80 Quite High
addiction 28 63.60 Quite High
dorsal root ganglion 26 60.88 Quite High
Disease Link Frequency Relevance Heat
Repression 1 98.20 Very High Very High Very High
Hyperalgesia 7 96.20 Very High Very High Very High
Necrosis 2 89.00 High High
Neurodegenerative Disease 1 88.52 High High
INFLAMMATION 74 78.40 Quite High
Death 3 75.00 Quite High
Apoptosis 2 71.44 Quite High
Ganglion Cysts 26 60.88 Quite High
Pain 63 39.00 Quite Low
Hyperphagia 1 13.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the expression of TLE1 and TLE4 in the Runx1-expressing neurons of the LPBS may indicate that the role of Runx1 in these cells may, at least in part, be mediated through the recruitment of Gro/TLE proteins and consequent transcriptional repression, although this possibility remains to be verified.
Gro Binding (recruitment) of in neurons associated with repression
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0.10 Pain Relevance 0.23
Stavudine administration did not affect the plasma concentration of IL-6, CINC-1, adiponectin or lactate.
CINC-1 Neg (not) Binding (concentration) of in plasma
2) Confidence 0.35 Published 2009 Journal Neurotoxicology Section Abstract Doc Link 19442827 Disease Relevance 0.81 Pain Relevance 0.88
Immunohistochemical staining of GRO/KC receptor CXCR2 in sectioned DRG tissue
GRO/KC Binding (receptor) of
3) Confidence 0.32 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.06
Incubation with GRO/KC enhances voltage-gated K currents in IB4-negative cells
GRO/KC Binding (Incubation) of in IB4
4) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2698898 Disease Relevance 0.06 Pain Relevance 0.03
In cells expressing cloned CXCR2 receptors, the binding constant for GRO/KC was 0.2 nM [37].
GRO/KC Binding (binding) of
5) Confidence 0.28 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0.20 Pain Relevance 0.32
Incubation with GRO/KC enhances Na+ current density without affecting other parameters
GRO/KC Binding (Incubation) of
6) Confidence 0.28 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0

General Comments

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