INT160148

Context Info Confidence 0.43 First Reported 2009 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 3 Disease Relevance 0.74 Pain Relevance 0.52

peptidase activity (Ctsl) histone binding (Ctsl) nucleolus (Ctsl) vacuole (Ctsl) lysosome (Ctsl) cytoplasm (Ctsl)

Ctsl (Mus musculus)

Pain Link Frequency Relevance Heat Pain 4 94.56 spinal stenosis 6 89.28 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Pain 4 94.56 Spinal Stenosis 6 89.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CONCLUSION: Although the application of tetanic stimulation prior to transcranial stimulation did not significantly increase the success rates of MEP recording, it significantly enlarged MEP amplitude under sevoflurane anesthesia in patients without preoperative motor deficits.

Neg (not) Positive_regulation (increase) of MEP

1) Confidence 0.43 Published 2009 Journal J Anesth Section Body Doc Link 19444553 Disease Relevance 0 Pain Relevance 0

The 17 patients with the increased TcMEP amplitudes had the greatest improvement 3 and 12 months postoperatively, based on neurological examination and the visual analog scale pain ratings (p<0.001).

Positive_regulation (increased) of TcMEP associated with pain

2) Confidence 0.39 Published 2010 Journal J Clin Neurosci Section Abstract Doc Link 20006509 Disease Relevance 0.37 Pain Relevance 0.26

In 17/25 patients there was an increase in TcMEP amplitudes of more than 50%, whereas in six patients the amplitudes only slightly increased or remained unchanged.

Positive_regulation (increase) of TcMEP

3) Confidence 0.28 Published 2010 Journal J Clin Neurosci Section Abstract Doc Link 20006509 Disease Relevance 0.37 Pain Relevance 0.26

General Comments

This test has worked.