INT16015

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Context Info
Confidence 0.37
First Reported 1973
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.95
Pain Relevance 2.90

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signal transduction (LHB) small molecule metabolic process (LHB) extracellular region (LHB)
cellular nitrogen compound metabolic process (LHB) cell-cell signaling (LHB)
Anatomy Link Frequency
pituitary gland 4
sperm 2
neural 2
LHB (Homo sapiens)
Pain Link Frequency Relevance Heat
Endogenous opioid 15 99.92 Very High Very High Very High
opiate 2 99.48 Very High Very High Very High
narcan 4 99.40 Very High Very High Very High
Fibrositis 77 92.88 High High
Opioid 4 89.60 High High
antagonist 11 87.72 High High
opioid receptor 2 87.68 High High
agonist 8 85.32 High High
headache 1 78.72 Quite High
withdrawal 1 76.64 Quite High
Disease Link Frequency Relevance Heat
Stress 16 99.62 Very High Very High Very High
Prolactinoma 2 99.08 Very High Very High Very High
Anovulation 1 97.56 Very High Very High Very High
Adverse Drug Reaction 1 96.44 Very High Very High Very High
Chronic Fatigue Syndrome 67 93.20 High High
Fibromyalgia 77 92.88 High High
Appetite Loss 2 83.36 Quite High
Vomiting 1 82.64 Quite High
Pressure And Volume Under Development 1 81.12 Quite High
Headache 1 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In pathophysiological states, they appear to play a role in the decreased pulsatile luteinizing hormone release seen in patients with prolactinomas.
Negative_regulation (decreased) of Localization (release) of luteinizing hormone associated with prolactinoma
1) Confidence 0.37 Published 1983 Journal Psychoneuroendocrinology Section Abstract Doc Link 6326175 Disease Relevance 0.26 Pain Relevance 0.54
In particular they appear to inhibit luteinizing hormone and ACTH release, and the response of arginine vasopressin to osmotic stimuli.
Negative_regulation (inhibit) of Localization (release) of luteinizing hormone
2) Confidence 0.31 Published 1983 Journal Psychoneuroendocrinology Section Abstract Doc Link 6326175 Disease Relevance 0.20 Pain Relevance 0.43
Oral contraceptive mechanisms include 1) blockage of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release, 2) alteration of motility in the fallopian tubes 3) modification of endometrial maturation, and 4) rendering the cervical mucus hostile to sperm migration.
Negative_regulation (blockage) of Localization (release) of luteinizing hormone in sperm
3) Confidence 0.26 Published 1973 Journal Am J Pharm Section Abstract Doc Link 12306537 Disease Relevance 0.78 Pain Relevance 0.14
Functional organization of the catecholaminergic neural systems inhibiting luteinizing hormone secretion in anestrous ewes.
Negative_regulation (inhibiting) of Localization (secretion) of luteinizing hormone in neural
4) Confidence 0.09 Published 1989 Journal Neuroendocrinology Section Title Doc Link 2812274 Disease Relevance 0 Pain Relevance 0.59
Stress has been shown to inhibit gonadotropin-releasing hormone and the pulsatile secretion of luteinizing hormone.
Negative_regulation (inhibit) of Localization (secretion) of luteinizing hormone associated with stress
5) Confidence 0.08 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416440 Disease Relevance 1.62 Pain Relevance 0.35
Endogenous opiates, such as beta-endorphin, inhibit the release of luteinizing hormone (LH) release in the pituitary gland of several species including rat, pig, sheep, and human.
Negative_regulation (inhibit) of Localization (release) of luteinizing hormone in pituitary gland associated with opiate
6) Confidence 0.07 Published 2004 Journal Neuroscience Section Abstract Doc Link 14960353 Disease Relevance 0 Pain Relevance 0.10
Endogenous opiates, such as beta-endorphin, inhibit the release of luteinizing hormone (LH) release in the pituitary gland of several species including rat, pig, sheep, and human.
Negative_regulation (inhibit) of Localization (release) of luteinizing hormone in pituitary gland associated with opiate
7) Confidence 0.07 Published 2004 Journal Neuroscience Section Abstract Doc Link 14960353 Disease Relevance 0 Pain Relevance 0.10
Evidence suggests that endogenous opioid peptides (EOP) inhibit pulsatile luteinizing hormone (LH) secretion during both the luteal and follicular phases of the ovine estrous cycle.
Negative_regulation (inhibit) of Localization (secretion) of luteinizing hormone associated with endogenous opioid
8) Confidence 0.04 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1784345 Disease Relevance 0 Pain Relevance 0.20
Role of endogenous opioids in reducing the frequency of pulsatile luteinizing hormone secretion induced by progesterone in normal women.
Negative_regulation (reducing) of Localization (secretion) of luteinizing hormone associated with narcan and endogenous opioid
9) Confidence 0.02 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 3652469 Disease Relevance 0 Pain Relevance 0.38
Follicular development and luteinizing hormone (LH) secretion are depressed during the last month of pregnancy.
Negative_regulation (depressed) of Localization (secretion) of luteinizing hormone
10) Confidence 0.01 Published 1995 Journal Reprod. Nutr. Dev. Section Abstract Doc Link 7546231 Disease Relevance 0.10 Pain Relevance 0.07

General Comments

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