INT160153

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.95
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Htr1a) plasma membrane (Htr1a) signal transducer activity (Htr1a)
Htr1a (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 14 100.00 Very High Very High Very High
Serotonin 211 98.60 Very High Very High Very High
fluoxetine 43 97.96 Very High Very High Very High
antidepressant 27 97.72 Very High Very High Very High
5HT 14 97.04 Very High Very High Very High
Pyramidal cell 24 91.68 High High
sSRI 13 89.44 High High
adenocard 4 87.36 High High
Neuronal excitability 1 85.24 High High
amygdala 6 77.52 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 46 98.80 Very High Very High Very High
Congenital Anomalies 4 98.76 Very High Very High Very High
Catalepsy 12 98.42 Very High Very High Very High
Targeted Disruption 105 97.70 Very High Very High Very High
Sprains And Strains 7 96.04 Very High Very High Very High
Depression 26 92.56 High High
Pathologic Processes 2 72.64 Quite High
Acidosis 57 70.44 Quite High
Pain 20 62.24 Quite High
Pressure And Volume Under Development 2 54.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No effect on cortical 5-HT1A and 5-HT2A receptor mRNA levels and on 5-HT1A receptor, tph2 (tryptophan hydroxylase-2) and SERT (serotonin transporter) mesencephalic gene expression was observed in ASC mice.
Gene_expression (levels) of 5-HT1A associated with serotonin
1) Confidence 0.65 Published 2009 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 19445393 Disease Relevance 0.74 Pain Relevance 0.55
[Effects of chronic fluoxetine treatment on catalepsy and immune response in mice genetically predisposed to freezing reaction: the role of 5-HT1A and 5-HT2A receptors and tph2 and SERT genes].
Gene_expression (role) of 5-HT1A associated with catalepsy and fluoxetine
2) Confidence 0.65 Published 2009 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Title Doc Link 19445393 Disease Relevance 0.80 Pain Relevance 0.54
An excess of endogenous 5-HT affects the expression of 5-HT1A receptors, the RRG modulation by 5-HT [36], [40] and may also affect non-5HT systems known to modulate the RRG such as the catecholaminergic system [41], [42].
Gene_expression (expression) of 5-HT1A associated with 5ht
3) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.07 Pain Relevance 0.42
In rodents, 5-HT1A receptor knockout mice have been shown to exhibit higher anxiety (Heisler et al. 1998; Parks et al. 1998; Ramboz et al. 1998) while overexpression of 5-HT1A receptors leads to decreased anxiety (Kusserow et al. 2004).
Gene_expression (overexpression) of 5-HT1A associated with targeted disruption and anxiety disorder
4) Confidence 0.57 Published 2010 Journal J Neurodev Disord Section Body Doc Link PMC2882561 Disease Relevance 0.62 Pain Relevance 0.28
It is notable that multiple 5-HT receptor null mutations that have been described, e.g. 5-HT1AR, 5-HT1BR, 5- HT2CR, 5-HT5AR, 5-HT2AR, 5- HT3R, and 5-HT6R, produce healthy animals with no overt abnormalities in appearance or behavior [1].
Gene_expression (produce) of 5-HT1AR associated with congenital anomalies
5) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.59 Pain Relevance 0.38
Normal physiology depends on maintaining a balance between 5HT2A receptor produced Ca++ inflow and 5HT1A receptor suppression of cAMP production.
Gene_expression (produced) of 5HT1A
6) Confidence 0.01 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.13 Pain Relevance 0.49
Following 5HT2A activation of PKC, 5HT1A receptors become unable to reduce serotonin production through negative feedback, and serotonin concentrations increase [32-34] E2 compounds this effect by directly inhibiting 5HT1A function [35,36].
Gene_expression (activation) of 5HT1A associated with kinase c and serotonin
7) Confidence 0.01 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0 Pain Relevance 0.57

General Comments

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