INT160159

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Context Info
Confidence 0.13
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90B2P) protein folding (HSP90B2P) small molecule metabolic process (CYP2C9)
oxidoreductase activity (CYP2C9) endoplasmic reticulum (CYP2C9) response to stress (HSP90B2P)
Anatomy Link Frequency
reticulum 2
CYP2C9 (Homo sapiens)
HSP90B2P (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 85.88 High High
Disease Link Frequency Relevance Heat
Stress 5 100.00 Very High Very High Very High
Shock 1 100.00 Very High Very High Very High
Hepatocellular Cancer 1 75.00 Quite High
Toxicity 1 52.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P450 2C9 overexpression induced endoplasmic reticulum (ER) stress and regulated genes implicated in the unfolded protein response (UPR) as heat shock protein (HSP) (we studied particurlarly HSPA5 and HSPB1) and in the endoplasmic reticulum associated degradation (ERAD) system as Sec61 and ubiquitin and proteasome pathways.
Gene_expression (overexpression) of P450 2C9 in reticulum Positive_regulation (induced) of HSP associated with stress and shock
1) Confidence 0.13 Published 2009 Journal Chem. Res. Toxicol. Section Abstract Doc Link 19445531 Disease Relevance 0.53 Pain Relevance 0.09

General Comments

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