INT160167

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.26
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde11a) signal transduction (Pde11a) cytoplasm (Pde11a)
Anatomy Link Frequency
nerve cell 1
Pde11a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 5 98.24 Very High Very High Very High
Pain 6 87.40 High High
Migraine 4 75.52 Quite High
ischemia 1 74.48 Quite High
Trigeminal neuralgia 1 73.92 Quite High
headache 2 70.24 Quite High
adenocard 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 5 97.80 Very High Very High Very High
Natriuresis 4 96.96 Very High Very High Very High
Pain 5 87.40 High High
Reprotox - General 2 3 86.56 High High
Cv Unclassified Under Development 1 74.48 Quite High
Headache 6 60.68 Quite High
Coronary Heart Disease 20 51.44 Quite High
Injury 9 5.00 Very Low Very Low Very Low
Hypertrophy 5 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry revealed that PDE9A, PDE10A and PDE11A are localised in the cytosol of nerve cell bodies of the trigeminal ganglion.
Localization (localised) of PDE11A in nerve cell associated with ganglion cysts and trigeminal ganglion
1) Confidence 0.77 Published 2009 Journal Brain Res. Section Abstract Doc Link 19445908 Disease Relevance 0.85 Pain Relevance 0.91
On the other hand, various phosphodiesterases regulate cGMP catabolism, including PDE-5A, PDE-6, PDE-9A, PDE-10A, and PDE-11A according to their tissue specificity [21-23].
Localization (catabolism) of PDE-11A
2) Confidence 0.15 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1131906 Disease Relevance 0.40 Pain Relevance 0.04

General Comments

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