INT160180

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 1.70
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
astrocytes 1
kidney 1
Fbxo23 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 19 97.88 Very High Very High Very High
tetrodotoxin 1 90.32 High High
Brush evoked pain 40 89.20 High High
GABAergic 1 88.08 High High
Nucleus accumbens 5 87.36 High High
agonist 9 83.12 Quite High
adenocard 25 81.92 Quite High
Pain 7 76.96 Quite High
withdrawal 16 65.28 Quite High
antagonist 1 60.08 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 102 100.00 Very High Very High Very High
Overdose 42 99.36 Very High Very High Very High
Body Weight 4 96.80 Very High Very High Very High
Targeted Disruption 1 96.36 Very High Very High Very High
Toxicity 6 94.72 High High
Neuropathic Pain 47 89.20 High High
Pain 6 76.96 Quite High
Nociception 17 5.00 Very Low Very Low Very Low
Death 13 5.00 Very Low Very Low Very Low
Vomiting 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In astrocytes GHB induced intracellular Ca(2+) transients, preserved in slices from GABA(B) receptor type 1 subunit knockout mice.
Positive_regulation (induced) of GHB in astrocytes associated with targeted disruption and gaba
1) Confidence 0.35 Published 2009 Journal Neuroscience Section Abstract Doc Link 19446011 Disease Relevance 0.10 Pain Relevance 0.59
Similarly, blood glucose and GHb for diabetic rats and diabetic rats treated with sulfasalazine, other salicylates, or PJ34 were significantly elevated compared with the normal controls throughout the study periods (Table 1).


Positive_regulation (elevated) of GHb in blood associated with diabetes mellitus
2) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2551692 Disease Relevance 0.92 Pain Relevance 0.42
These results suggest that administration of MCT inhibitors presents a possible clinical strategy for increasing GHB elimination in overdose cases.
Spec (possible) Positive_regulation (increasing) of GHB associated with overdose
3) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.19 Pain Relevance 0
As the inhibition of MCTs results in altered GHB uptake in kidney cells, further studies investigated potential strategies for increasing the renal elimination of GHB by administrating the MCT substrates l-lactate and pyruvate (6).
Positive_regulation (increasing) of GHB in kidney
4) Confidence 0.02 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.12 Pain Relevance 0
Additional in vitro and in vivo studies were conducted to evaluate novel MCT inhibitors and their potential to increase GHB renal clearance and overall pharmacokinetics.
Positive_regulation (increase) of GHB
5) Confidence 0.02 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.18 Pain Relevance 0.03
To further explore the influence of MCT1 on GHB renal reabsorption, studies were conducted to assess the modulation of MCT1-mediated GHB transport through the evaluation of potential inhibitors.
Positive_regulation (mediated) of GHB
6) Confidence 0.02 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0
Concomitant administration of GHB and l-lactate to rats results in an approximately two-fold increase in GHB renal clearance suggesting that inhibition of MCT1-mediated reabsorption of GHB may be an effective strategy for increasing renal and total GHB elimination in overdose situations.
Positive_regulation (increasing) of GHB associated with overdose
7) Confidence 0.02 Published 2008 Journal AAPS J Section Abstract Doc Link PMC2574616 Disease Relevance 0.10 Pain Relevance 0
Concomitant administration of GHB and l-lactate to rats results in an approximately two-fold increase in GHB renal clearance suggesting that inhibition of MCT1-mediated reabsorption of GHB may be an effective strategy for increasing renal and total GHB elimination in overdose situations.
Positive_regulation (increase) of GHB associated with overdose
8) Confidence 0.02 Published 2008 Journal AAPS J Section Abstract Doc Link PMC2574616 Disease Relevance 0.09 Pain Relevance 0

General Comments

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