INT160181

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.63
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nucleus accumbens 1
astrocytes 1
kidney 1
Fbxo23 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 22 99.84 Very High Very High Very High
antagonist 2 98.80 Very High Very High Very High
Potency 6 98.16 Very High Very High Very High
Nucleus accumbens 10 97.88 Very High Very High Very High
Neurotransmitter 1 91.32 High High
agonist 5 89.20 High High
tetrodotoxin 2 88.88 High High
GABAergic 2 84.32 Quite High
Inflammation 2 82.32 Quite High
cINOD 4 80.80 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 87.52 High High
INFLAMMATION 2 82.32 Quite High
Overdose 21 76.64 Quite High
Toxicity 3 72.60 Quite High
Death 6 50.36 Quite High
Coma 3 49.96 Quite Low
Unconsciousness 3 48.84 Quite Low
Vomiting 6 48.04 Quite Low
Dizziness 3 47.32 Quite Low
Convulsion 3 46.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
gamma-Hydroxybutyrate (GHB) induces GABA(B) receptor independent intracellular Ca2+ transients in astrocytes, but has no effect on GHB or GABA(B) receptors of medium spiny neurons in the nucleus accumbens.
Neg (no) Regulation (effect) of GHB in nucleus accumbens associated with nucleus accumbens and gaba
1) Confidence 0.50 Published 2009 Journal Neuroscience Section Title Doc Link 19446011 Disease Relevance 0.07 Pain Relevance 0.57
GHB-induced astrocytic Ca(2+) transients were not affected by the GHB receptor-specific antagonist NCS-382, suggesting the presence of a novel NCS-382-insensitive target for GHB in astrocytes.
Neg (not) Regulation (affected) of GHB-induced in astrocytes associated with antagonist
2) Confidence 0.36 Published 2009 Journal Neuroscience Section Abstract Doc Link 19446011 Disease Relevance 0.09 Pain Relevance 0.64
To separate specific GHB effects from GABA(B) receptor effects, it is imperative to develop GHB selective and potent compounds.
Regulation (effects) of GHB associated with gaba
3) Confidence 0.20 Published 2009 Journal Fundam Clin Pharmacol Section Abstract Doc Link 19645815 Disease Relevance 0.16 Pain Relevance 0.34
In vitro studies have characterized the renal transport mechanisms of GHB and elucidated the MCT isoforms contributing to GHB reuptake.
Regulation (contributing) of GHB
4) Confidence 0.02 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.18 Pain Relevance 0.03
In contrast, the flavonoid glycosides had minimal effects on GHB uptake (94).
Regulation (effects) of GHB
5) Confidence 0.02 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.14 Pain Relevance 0.05
However, based on the expression patterns of MCTs in the kidney, MCT1 is likely the primary isoform responsible for GHB renal uptake.
Regulation (responsible) of GHB in kidney
6) Confidence 0.02 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0

General Comments

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