INT16022

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Context Info
Confidence 0.66
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.43
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppia) protein folding (Ppia) cytosol (Ppia)
nucleus (Ppia) cytoplasm (Ppia)
Anatomy Link Frequency
beta cells 1
Ppia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 292 98.88 Very High Very High Very High
Opioid 1 88.72 High High
Hippocampus 6 52.16 Quite High
anesthesia 5 48.28 Quite Low
Enkephalin 1 25.00 Low Low
long-term potentiation 11 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Somatostatin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 4 99.98 Very High Very High Very High
Aids-related Complex 70 90.16 High High
Neurodegenerative Disease 22 23.68 Low Low
Body Weight 1 5.44 Low Low
Stress 28 5.00 Very Low Very Low Very Low
Cognitive Disorder 14 5.00 Very Low Very Low Very Low
Death 11 5.00 Very Low Very Low Very Low
Diabetes Mellitus 9 5.00 Very Low Very Low Very Low
Cocaine Dependence 7 5.00 Very Low Very Low Very Low
Hypoglycemia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transcript encoding peptidyl-prolyl cis-trans isomerase is constitutively expressed.
Gene_expression (expressed) of peptidyl-prolyl cis-trans isomerase
1) Confidence 0.66 Published 1991 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 1785782 Disease Relevance 0 Pain Relevance 0.09
Since pRc/CMV-CycA transfection (with ?
Gene_expression (transfection) of CycA associated with cytomegalovirus infection
2) Confidence 0.58 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.26 Pain Relevance 0.53
S1: 2 cytoskeleton- (Tubb5, Pfn1), 2 signaling- (Ywhae, Rab1b) and 2 protein synthesis (Ppia, Hspa8)-associated proteins, and spread over a concentration range of 2 decades.


Gene_expression (synthesis) of Ppia
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997773 Disease Relevance 0 Pain Relevance 0
From 3 different functional pathways, 2 proteins were chosen: cytoskeleton (Tubb5, Pfn1), cell signaling (Ywhae, Rab1b) and protein synthesis (Ppia, Hspa8).
Gene_expression (synthesis) of Ppia
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997773 Disease Relevance 0 Pain Relevance 0
Ppia, Hspa8, Tubb5, Pfn1, Ywhae and Rab1b were selected in the tissue-comparative data set, and successfully validated in the independently acquired data set on highly/lowly glucose responsive beta cells.
Gene_expression (selected) of Ppia in beta cells
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997773 Disease Relevance 0 Pain Relevance 0
Data

were normalized with the geometric mean of the three normalization genes polyubiquitin, Cyclophilin,

Gene_expression (normalized) of Cyclophilin
6) Confidence 0.17 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.17 Pain Relevance 0.03

General Comments

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