INT160241

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.33
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
skin 2
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
psoriasis 7 99.48 Very High Very High Very High
cytokine 130 99.08 Very High Very High Very High
methotrexate 50 97.36 Very High Very High Very High
Inflammatory response 23 96.36 Very High Very High Very High
Inflammation 202 90.84 High High
adenocard 75 85.68 High High
rheumatoid arthritis 64 78.44 Quite High
Arthritis 92 72.52 Quite High
Analgesic 1 54.88 Quite High
antagonist 26 50.76 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 82 100.00 Very High Very High Very High
Psoriasis 7 99.48 Very High Very High Very High
Necrosis 11 98.68 Very High Very High Very High
Gastritis 9 98.48 Very High Very High Very High
Cancer 8 98.32 Very High Very High Very High
INFLAMMATION 224 96.00 Very High Very High Very High
Multiple Sclerosis 7 93.88 High High
Mycobacterial Infection 4 93.84 High High
Repression 1 89.80 High High
Chronic Hepatitis 1 83.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A marked decrease of IFNgamma(+)- and increase of IL-10(+)-producing cells compared with the gastritis group mice were observed.
Negative_regulation (decrease) of Positive_regulation (increase) of IL-10 associated with gastritis
1) Confidence 0.39 Published 2009 Journal J. Dairy Sci. Section Abstract Doc Link 19447974 Disease Relevance 1.05 Pain Relevance 0.14
The increase of IL-10 was augmented in mice pretreated with 7-NINA or L-NAME, but reduced in mice receiving AG or L-NIO, at 6 and 16 h after CFA (Fig. 4C, P < 0.05 and P < 0.001).


Negative_regulation (reduced) of Positive_regulation (increase) of IL-10
2) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.29 Pain Relevance 0.12
levels and increased IL-10 levels in wild-type mice and A3 knockout mice, but only marginally decreased TNF-?
Negative_regulation (decreased) of Positive_regulation (increased) of IL-10 associated with targeted disruption
3) Confidence 0.29 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.50 Pain Relevance 0.70
However, diminished production of IL-10 mRNA and IL-10 protein in term and preterm neonates compared with adults was observed after stimulating with LPS (Schultz et al., 2004).
Negative_regulation (diminished) of Positive_regulation (production) of IL-10 protein
4) Confidence 0.24 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.79 Pain Relevance 0.19
However, diminished production of IL-10 mRNA and IL-10 protein in term and preterm neonates compared with adults was observed after stimulating with LPS (Schultz et al., 2004).
Negative_regulation (diminished) of Positive_regulation (production) of IL-10
5) Confidence 0.24 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.79 Pain Relevance 0.19
A possible explanation for this discrepancy could be the inhibited induction of IL-10 in the IL-23 polarized cells.
Negative_regulation (inhibited) of Positive_regulation (induction) of IL-10
6) Confidence 0.08 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.59 Pain Relevance 0.14
Clinical studies performed in patients with psoriasis showed that subcutaneous injections of IL-10 improved skin lesions and reduced the expression of Th1 cytokines (Asadullah et al 2003), thus suggesting an IL-10-induced shift from Th1 to Th2 immune response.
Negative_regulation (reduced) of Positive_regulation (injections) of IL-10 in skin associated with psoriasis and cytokine
7) Confidence 0.07 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.32 Pain Relevance 0.45

General Comments

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