INT160251

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Context Info
Confidence 0.63
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 48
Total Number 48
Disease Relevance 37.14
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Myo5a) Golgi apparatus (Myo5a) cytoplasm (Myo5a)
Anatomy Link Frequency
blood 2
arm 2
band 2
motor neuron 2
B cells 1
Myo5a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor antagonist 4 100.00 Very High Very High Very High
Potency 8 99.28 Very High Very High Very High
Inflammatory response 12 98.66 Very High Very High Very High
imagery 380 96.60 Very High Very High Very High
headache 25 96.40 Very High Very High Very High
Pain 33 95.80 Very High Very High Very High
anesthesia 26 93.32 High High
isoflurane 14 92.88 High High
Inflammation 99 90.96 High High
Pyramidal cell 45 86.60 High High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 677 100.00 Very High Very High Very High
Syndrome 170 100.00 Very High Very High Very High
Mevalonate Kinase Deficiency 76 100.00 Very High Very High Very High
Mycobacterial Infection 76 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

12 100.00 Very High Very High Very High
Motor Neuron Diseases 760 99.94 Very High Very High Very High
Malaria 127 99.88 Very High Very High Very High
Pox Virus Infection 259 99.84 Very High Very High Very High
Rabies Virus Infection 20 99.76 Very High Very High Very High
Diarrhoea 20 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we have demonstrated that immunization with a recombinant MVA expressing the HA gene of influenza H5N1 virus A/Vietnam/1194/04 (MVA-HA-VN/04) induced protective immunity against infection with the homologous and a heterologous antigenically distinct virus in mice and macaques [24], [25].
Gene_expression (expressing) of MVA associated with influenza virus infection, immunization and infection
1) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771904 Disease Relevance 0.89 Pain Relevance 0
Modified vaccinia virus Ankara expressing T7 RNA polymerase (MVA-T7) was kindly provided by G.
Gene_expression (expressing) of MVA associated with pox virus infection
2) Confidence 0.58 Published 2010 Journal Virol J Section Body Doc Link PMC2887800 Disease Relevance 1.28 Pain Relevance 0
Recently, we have demonstrated that immunization with a recombinant MVA expressing the HA gene of influenza H5N1 virus A/Vietnam/1194/04 (MVA-HA-VN/04) induced protective immunity against infection with the homologous and a heterologous antigenically distinct virus in mice and macaques [24], [25].
Gene_expression (expressing) of MVA-HA-VN/04 associated with influenza virus infection, immunization and infection
3) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771904 Disease Relevance 0.95 Pain Relevance 0
Recombinant MVA expressing the HA gene of influenza virus A/Vietnam/1194/04 (MVA-HA-VN/04) was prepared as described previously [25].
Gene_expression (expressing) of MVA associated with influenza virus infection
4) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771904 Disease Relevance 0.33 Pain Relevance 0
To this end, mice were vaccinated once or twice with descending doses of a recombinant MVA expressing the HA gene of influenza virus A/Vietnam/1194/04.
Gene_expression (expressing) of MVA associated with influenza virus infection
5) Confidence 0.49 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2771904 Disease Relevance 0.64 Pain Relevance 0
Recombinant MVA expressing the HA gene of influenza virus A/Vietnam/1194/04 (MVA-HA-VN/04) was prepared as described previously [25].
Gene_expression (expressing) of MVA-HA-VN/04 associated with influenza virus infection
6) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771904 Disease Relevance 0.33 Pain Relevance 0
In the present study, the minimal requirements were assessed for the induction of protective immunity in mice against antigenically distinct influenza A/H5N1 viruses with a recombinant MVA expressing the HA gene of a clade 1 influenza A/H5N1virus.
Gene_expression (expressing) of MVA associated with influenza virus infection
7) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771904 Disease Relevance 0.70 Pain Relevance 0
Our results indicated that several genes known to be part of the inflammatory response were found downstream of PAR1 activation (b2m, ccl7, cd200, cd63, cdbpd, cfl1, dusp1, fkbp1a, fth1, hspb1, marcksl1, mmp2, myo5a, nfkbia, pax1, plaur, ppia, ptpn1, ptprcap, s100a10, sim2, and tnfaip2).
Gene_expression (cdbpd) of myo5a associated with inflammatory response
8) Confidence 0.31 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.87 Pain Relevance 0.35
In order to assess HA antigen levels and processing, expression experiments in MVA-permissive avian cells were performed.
Gene_expression (expression) of MVA
9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.59 Pain Relevance 0
The neuraminidase containing MVA viruses were partially protective and neuraminidase-inhibiting antibodies were detectable, consistent with earlier findings indicating that anti-NA antibodies do not neutralize influenza virus but interfere with virus release from the host cells resulting in reduction of titers [29].
Gene_expression (containing) of MVA associated with influenza virus infection
10) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.95 Pain Relevance 0
With the neuraminidase construct, MVA-N1-Ca, partial protection was achieved.
Gene_expression (protection) of MVA
11) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.15 Pain Relevance 0
A further advantage of using MVA as pandemic influenza vaccine is its genetic stability including that of the expressed foreign genes.
Gene_expression (expressed) of MVA associated with influenza virus infection
12) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 1.13 Pain Relevance 0.04
The large band at around 80 kDa represents the HA0 hemagglutinin-precursor, which is not cleaved in cells lacking the required proteases such as the chicken cells used to propagate MVA (lanes 4 and 6).
Gene_expression (propagate) of MVA in band
13) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.33 Pain Relevance 0
The purpose of this study was to evaluate the immune response and the protective potential of MVA-based influenza vaccines expressing the protective antigens hemagglutinin and neuraminidase of the novel H1N1 strain.
Gene_expression (expressing) of MVA associated with influenza virus infection and sprains and strains
14) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.41 Pain Relevance 0
In vivo, BLI is highly sensitive to luciferase-expressing cells and detects them even early after cell inoculation; however, one should note that the time course of the signal after d-luciferin injection may be delayed because the blood supply to the tumor has not been established early after cell inoculation.
Gene_expression (injection) of d-luciferin in blood associated with cancer and imagery
15) Confidence 0.15 Published 2010 Journal International Journal of Biomedical Imaging Section Body Doc Link PMC2910476 Disease Relevance 0.61 Pain Relevance 0.05
In summary, the time course of bioluminescence signals after d-luciferin injection varies over days after cell inoculation in mice bearing subcutaneous tumors, and such variation should be considered when determining the imaging protocol and the method of quantitative analysis.
Gene_expression (injection) of d-luciferin associated with cancer and imagery
16) Confidence 0.15 Published 2010 Journal International Journal of Biomedical Imaging Section Body Doc Link PMC2910476 Disease Relevance 0.99 Pain Relevance 0.33
min after d-luciferin injection.
Gene_expression (injection) of d-luciferin
17) Confidence 0.15 Published 2010 Journal International Journal of Biomedical Imaging Section Body Doc Link PMC2910476 Disease Relevance 0.13 Pain Relevance 0.33
min) after d-luciferin injection were determined as alternatives to the peak signal.
Gene_expression (injection) of d-luciferin
18) Confidence 0.15 Published 2010 Journal International Journal of Biomedical Imaging Section Body Doc Link PMC2910476 Disease Relevance 0.32 Pain Relevance 0.15
We recommend evaluating the relationship between the time course of signals after d-luciferin injection and the number of days after cell inoculation in preliminary experiments using a small number of animals.
Gene_expression (injection) of d-luciferin
19) Confidence 0.15 Published 2010 Journal International Journal of Biomedical Imaging Section Body Doc Link PMC2910476 Disease Relevance 0.42 Pain Relevance 0.18
The signal at a fixed time point after d-luciferin injection was closely correlated with the peak signal, irrespective of the time point used for analysis, apparently justifying the single-point imaging strategy.
Gene_expression (injection) of d-luciferin associated with imagery
20) Confidence 0.15 Published 2010 Journal International Journal of Biomedical Imaging Section Body Doc Link PMC2910476 Disease Relevance 0.50 Pain Relevance 0.16

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