INT160252

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Context Info
Confidence 0.21
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.49
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C1s) extracellular region (C1s)
Anatomy Link Frequency
neurons 1
promyelocytes 1
C1s (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 13 68.56 Quite High
antagonist 2 25.60 Quite Low
Antinociceptive 1 25.00 Low Low
hypoalgesia 1 25.00 Low Low
Inflammatory response 2 15.44 Low Low
member 8 12 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
cerebral cortex 10 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

12 100.00 Very High Very High Very High
Diarrhoea 1 100.00 Very High Very High Very High
Reprotox - General 1 2 98.88 Very High Very High Very High
Inflammatory Bowel Disease 11 88.16 High High
INFLAMMATION 15 68.56 Quite High
Myocardial Infarction 49 54.36 Quite High
Coronary Artery Disease 16 53.44 Quite High
Heart Disease 2 52.04 Quite High
Glomerulonephritis 23 51.28 Quite High
Paroxysmal Nocturnal Hemoglobinuria 27 50.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated C1s cleaves C4 and C2 to form C4b and C2b, respectively, which then combine to form the C3 convertase of the classical complement pathway (Figure 1).
Gene_expression (cleaves) of C1s
1) Confidence 0.21 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.26 Pain Relevance 0
Elevated colonic luminal serine-protease (Ser-P) activity of diarrhea-predominant IBS (IBS-D) patients evokes a proteinase-activated receptor (PAR)-2-mediated colonic hypersensitivity in mice.
Gene_expression (evokes) of serine-protease associated with diarrhoea
2) Confidence 0.14 Published 2009 Journal Pain Section Abstract Doc Link 19450926 Disease Relevance 0.46 Pain Relevance 0
In addition, expression of other serine protease inhibitors has been described in other migrating neurons.
Gene_expression (expression) of serine protease in neurons
3) Confidence 0.05 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0 Pain Relevance 0
The highly related serine protease known also as neutrophil elastase, proteinase 3 and cathepsin G are exclusively detected in promyelocytes and packaged in azurophil granules [57,58], whereas carbonic anhydrase 1 is expressed in adult human and mouse erythroid cells and colon epithelia, from two distinct promoters [59].
Gene_expression (detected) of serine protease in promyelocytes
4) Confidence 0.05 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.07 Pain Relevance 0.03
Since prostate-specific antigen (PSA), also known as gamma-seminoprotein, is a serine protease produced and secreted abundantly by prostate cancer cells [38], we did not detect PSA in the current results on normal prostate.
Gene_expression (produced) of serine protease associated with reprotox - general 1
5) Confidence 0.05 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.10 Pain Relevance 0

General Comments

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