INT160258

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.96
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Myo5a) Golgi apparatus (Myo5a) cytoplasm (Myo5a)
Myo5a (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 75.92 Quite High
hypoalgesia 1 55.52 Quite High
headache 1 37.76 Quite Low
abdominal pain 1 33.40 Quite Low
Antinociceptive 1 31.28 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
anakinra 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 38 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

12 100.00 Very High Very High Very High
Inflammatory Bowel Disease 11 100.00 Very High Very High Very High
Weight Loss 20 99.24 Very High Very High Very High
Congenital Anomalies 8 95.36 Very High Very High Very High
Sprains And Strains 40 94.56 High High
Infection 93 92.64 High High
Influenza Virus Infection 102 87.20 High High
Nociception 1 82.16 Quite High
Fever 21 81.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, since MVA is fully replication deficient, pre-existing immunity is unlikely to affect the immunogenicity of these vector vaccines to a great extent and did not prevent the induction of humoral responses to the expressed protein [35]–[37].
Negative_regulation (deficient) of MVA
1) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771904 Disease Relevance 0.47 Pain Relevance 0
Only with a high dose of MVA-HA-VN/04 (?
Negative_regulation (dose) of MVA-HA-VN/04
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771904 Disease Relevance 0.49 Pain Relevance 0
Fecal protease activities were assayed in healthy subjects, IBS-D and UC patients in presence or not of antiproteases or Cat-G inhibitor.
Negative_regulation (inhibitor) of IBS-D associated with inflammatory bowel disease
3) Confidence 0.05 Published 2009 Journal Pain Section Abstract Doc Link 19450926 Disease Relevance 0.95 Pain Relevance 0.09
As the absolute level of mevalonic acid is always elevated in patients with MVK deficiency, samples from patients with a suspected MVA deficiency should undergo a sensitive measurement of mevalonic acid by stable isotope dilution analysis to detect even slight abnormalities.
Negative_regulation (deficiency) of MVA associated with mevalonate kinase deficiency and congenital anomalies
4) Confidence 0.03 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1475558 Disease Relevance 1.31 Pain Relevance 0

General Comments

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