INT1603

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Context Info
Confidence 0.51
First Reported 1978
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 131
Total Number 132
Disease Relevance 29.99
Pain Relevance 66.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rtcd1) molecular_function (Rtcd1) ligase activity (Rtcd1)
Anatomy Link Frequency
NG108-15 5
paw 3
neurons 3
brain 2
HEK 2
Rtcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 204 100.00 Very High Very High Very High
Opioid 129 100.00 Very High Very High Very High
Dopamine 30 100.00 Very High Very High Very High
Dynorphin 7 100.00 Very High Very High Very High
agonist 172 99.98 Very High Very High Very High
opiate 91 99.98 Very High Very High Very High
Immobilon 24 99.98 Very High Very High Very High
noradrenaline 7 99.98 Very High Very High Very High
hyperexcitability 10 99.92 Very High Very High Very High
potassium channel 4 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Vibrio Infection 34 100.00 Very High Very High Very High
Ganglion Cysts 34 99.68 Very High Very High Very High
Bordatella Infection 47 99.66 Very High Very High Very High
Apoptosis 18 99.66 Very High Very High Very High
Cytomegalovirus Infection 1 99.36 Very High Very High Very High
Sprains And Strains 10 99.28 Very High Very High Very High
Neuroblastoma 37 99.24 Very High Very High Very High
Glioma 32 99.02 Very High Very High Very High
Nociception 33 98.96 Very High Very High Very High
Hyperalgesia 20 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rapid receptor mediated inhibition of adenylate cyclase is followed by a long-lived compensatory increase in its activity (1-4).
Negative_regulation (inhibition) of cyclase
1) Confidence 0.51 Published 1983 Journal Life Sci. Section Abstract Doc Link 6686637 Disease Relevance 0.50 Pain Relevance 1.00
G-proteins that inhibit adenylate cyclase activity mediate the activity of the 5-HT2B receptor subunit, which is widely expressed in a variety of tissues, including liver, lung, heart, and coronary and pulmonary arteries; it has also been reported in embryonic mouse heart, particularly on mouse heart valve leaflets.
Negative_regulation (inhibit) of cyclase in liver
2) Confidence 0.37 Published 2009 Journal J Am Soc Echocardiogr Section Abstract Doc Link 19553085 Disease Relevance 0.63 Pain Relevance 0.39
The antinociceptive effect caused by selenide (50 mg/kg, p.o.) on the formalin test was reversed by pretreatment with N(G)-L-nitro-arginine methyl ester (L-NAME, a nitric oxide (NO) synthase inhibitor), methylene blue (a non-specific NO/guanylyl cyclase inhibitor) and glibenclamide (an ATP-sensitive K(+) channel inhibitor), but not by atropine (a muscarinic antagonist).
Neg (NO) Negative_regulation (inhibitor) of cyclase associated with antagonist and antinociceptive
3) Confidence 0.36 Published 2007 Journal Life Sci. Section Abstract Doc Link 18031763 Disease Relevance 0.27 Pain Relevance 0.59
The relaxation was reduced also by apamin (0.1 microM) and by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; 1 microM), a guanylyl cyclase inhibitor.
Negative_regulation (inhibitor) of cyclase
4) Confidence 0.34 Published 2003 Journal Nitric Oxide Section Abstract Doc Link 12586541 Disease Relevance 0 Pain Relevance 0.07
In the cavernous strips precontracted with phenylephrine, transmural electrical stimulation elicited frequency-dependent (2 - 5 Hz) relaxations that were abolished by N(G)-nitro-L-arginine (10(-5) M), a nitric oxide (NO) synthase inhibitor; 1H[1,2,4]oxadiazole[4,3-a]quinoxalin-1-one (ODQ, 10(-6) M), a soluble guanylate cyclase inhibitor; and tetrodotoxin (3 x 10(-7) M).
Negative_regulation (inhibitor) of cyclase associated with tetrodotoxin
5) Confidence 0.28 Published 2001 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11885970 Disease Relevance 0 Pain Relevance 0.29
In addition, a unique coupling and inhibition of adenosine diphosphate-ribosyl cyclase have also been described.
Negative_regulation (inhibition) of cyclase associated with adenocard
6) Confidence 0.28 Published 2010 Journal Curr Top Med Chem Section Abstract Doc Link 20166946 Disease Relevance 0.41 Pain Relevance 0.41
Herein we describe the use of intracavernous methylene blue (MB), a guanylate cyclase inhibitor, or internal pudendal artery embolization for the treatment of priapism.
Negative_regulation (inhibitor) of cyclase in pudendal artery associated with reprotox - general 2
7) Confidence 0.28 Published 1998 Journal Int. J. Impot. Res. Section Abstract Doc Link 9542685 Disease Relevance 0.57 Pain Relevance 0.03
Methylene blue, a guanylate cyclase inhibitor, was not able to antagonize the hypotensive activity of melatonin, suggesting that the mechanism of action of melatonin does not involve guanylate cyclase.
Negative_regulation (inhibitor) of cyclase associated with hypotension
8) Confidence 0.28 Published 2000 Journal Pharmacol. Toxicol. Section Abstract Doc Link 10752670 Disease Relevance 0.33 Pain Relevance 0.17
Opiate stimulation of GTPase and inhibition of adenylyl cyclase were fully expressed prenatally.
Negative_regulation (inhibition) of cyclase associated with opiate
9) Confidence 0.14 Published 1991 Journal FEBS Lett. Section Abstract Doc Link 1652479 Disease Relevance 0 Pain Relevance 0.10
A and E produced a rapid cAMP hydrolysis on stimulating the activity of FDE, M and DE inhibited apparently adenylate cyclase.
Negative_regulation (inhibited) of cyclase
10) Confidence 0.13 Published 1981 Journal Tsitologiia Section Abstract Doc Link 6266087 Disease Relevance 0.49 Pain Relevance 0.12
G-proteins that inhibit adenylate cyclase activity mediate the activity of the 5-HT2B receptor subunit, which is widely expressed in a variety of tissues, including liver, lung, heart, and coronary and pulmonary arteries; it has also been reported in embryonic mouse heart, particularly on mouse heart valve leaflets.
Negative_regulation (inhibit) of cyclase in heart
11) Confidence 0.13 Published 2009 Journal J Am Soc Echocardiogr Section Abstract Doc Link 19553085 Disease Relevance 0.63 Pain Relevance 0.39
G-proteins that inhibit adenylate cyclase activity mediate the activity of the 5-HT2B receptor subunit, which is widely expressed in a variety of tissues, including liver, lung, heart, and coronary and pulmonary arteries; it has also been reported in embryonic mouse heart, particularly on mouse heart valve leaflets.
Negative_regulation (inhibit) of cyclase in lung
12) Confidence 0.13 Published 2009 Journal J Am Soc Echocardiogr Section Abstract Doc Link 19553085 Disease Relevance 0.63 Pain Relevance 0.39
Blockade of nitric oxide-evoked smooth muscle contractions by an inhibitor of guanylyl cyclase.
Negative_regulation (inhibitor) of cyclase in smooth muscle
13) Confidence 0.11 Published 1997 Journal Neuroreport Section Title Doc Link 9351671 Disease Relevance 0 Pain Relevance 0.12
Neuroblastoma x glioma in NG108-15 cells possess opiate, alpha-adrenergic, and muscarinic acetylcholine receptors, which mediate an inhibition of adenylate cyclase.
Negative_regulation (inhibition) of cyclase in NG108-15 associated with neuroblastoma, opiate and glioma
14) Confidence 0.10 Published 1978 Journal Natl Cancer Inst Monogr Section Abstract Doc Link 219360 Disease Relevance 0.27 Pain Relevance 0.33
Muscarinic cholinergic inhibition of adenylate cyclase in the rabbit iris-ciliary body and ciliary epithelium.
Negative_regulation (inhibition) of cyclase in iris
15) Confidence 0.10 Published 1990 Journal Invest. Ophthalmol. Vis. Sci. Section Title Doc Link 2162335 Disease Relevance 0 Pain Relevance 0.14
It was first demonstrated that carnosine is a selective inhibitor of NO-dependent activation of guanylate cyclase and may be used for suppression of activity of the intracellular signaling system NO-soluble guanylate cyclase-cGMP, whose sharp increase is observed in malignant tumors, sepsis, septic shock, asthma, and migraine.
Negative_regulation (suppression) of cyclase associated with asthma, malignant neoplastic disease, migraine and sepsis
16) Confidence 0.10 Published 2000 Journal Biochemistry Mosc. Section Abstract Doc Link 10951096 Disease Relevance 0.49 Pain Relevance 0.10
Methylene blue (MB), a guanylyl cyclase and/or NOS inhibitor, (5-160 mg/kg) also produced a dose-dependent triphasic response.
Negative_regulation (inhibitor) of cyclase
17) Confidence 0.09 Published 2000 Journal Life Sci. Section Abstract Doc Link 10954047 Disease Relevance 0.32 Pain Relevance 0.48
The inhibition of cGMP formation by 1H-[1,2,4] oxodizao [4,3-a] quinoxalin-1-one (ODQ), a selective inhibitor for NO-sensitive guanylate cyclase, showed no affects on the ionomycin-evoked [3H]GABA release.
Negative_regulation (inhibitor) of cyclase associated with gaba
18) Confidence 0.09 Published 2002 Journal J. Neurochem. Section Abstract Doc Link 12067225 Disease Relevance 0 Pain Relevance 0.50
As expected, stimulation of mu, delta, and D2 receptors on brain tissue of wild-type animals induced a dose-dependent decrease in adenylate cyclase activity, whereas a striking mirror effect was observed in mutants.
Negative_regulation (decrease) of cyclase in brain
19) Confidence 0.09 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11880531 Disease Relevance 0.56 Pain Relevance 1.27
Such a hypothesis is in agreement with observations indicating that 17 beta-estradiol both suppressed the D2 dopamine- and opiate receptor-induced inhibitions of adenylate cyclase activity and enhanced the positive coupling between biogenic amine receptors (D1 dopamine, beta-adrenergic, and A2 adenosine) and adenylate cyclase.
Negative_regulation (inhibitions) of cyclase associated with adenocard, dopamine and opiate
20) Confidence 0.09 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2118945 Disease Relevance 0.23 Pain Relevance 0.28

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