INT160304

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.43
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) aging (Fos) extracellular region (Npy)
nucleolus (Fos) nucleus (Fos) DNA binding (Fos)
Anatomy Link Frequency
CTNs 2
cuneate nucleus 2
neurons 2
Npy (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 6 100.00 Very High Very High Very High
antagonist 5 99.64 Very High Very High Very High
Eae 2 97.76 Very High Very High Very High
projection neuron 6 97.24 Very High Very High Very High
Intracerebroventricular 2 94.96 High High
lidocaine 8 94.08 High High
Neuropathic pain 4 90.52 High High
central sensitization 1 90.08 High High
allodynia 2 89.92 High High
Thermal hyperalgesia 2 78.72 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 2 97.84 Very High Very High Very High
Nervous System Injury 5 96.32 Very High Very High Very High
Injury 10 96.08 Very High Very High Very High
Neuropathic Pain 6 90.52 High High
Hyperalgesia 2 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuropeptide Y modulates c-Fos protein expression in the cuneate nucleus and contributes to mechanical hypersensitivity following rat median nerve injury.
Neuropeptide Y Regulation (modulates) of Gene_expression (expression) of c-Fos in cuneate nucleus associated with nervous system injury, hypersensitivity and neuropeptide
1) Confidence 0.67 Published 2009 Journal J. Neurotrauma Section Title Doc Link 19456245 Disease Relevance 0.52 Pain Relevance 0.33
Furthermore, expression of c-Fos-LI neurons in the CN was significantly reduced by an NPY receptor antagonist, indicating that NPY modulated c-Fos expression following MNT.
NPY Regulation (modulated) of Gene_expression (expression) of c-Fos in neurons associated with antagonist
2) Confidence 0.67 Published 2009 Journal J. Chem. Neuroanat. Section Abstract Doc Link 19559985 Disease Relevance 0.30 Pain Relevance 0.68
Furthermore, the number of c-Fos-LI cells as well as the percentage of c-Fos-LI cuneothalamic projection neurons (CTNs) in the CN was markedly decreased after injection of NPY receptor antagonist along with retrograde tract-tracing method, indicating that NPY regulated c-Fos expression.
NPY Regulation (regulated) of Gene_expression (expression) of c-Fos in CTNs associated with antagonist and projection neuron
3) Confidence 0.29 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19456245 Disease Relevance 0.61 Pain Relevance 0.67

General Comments

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