INT160329

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Context Info
Confidence 0.60
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 4.08
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cort)
Anatomy Link Frequency
adrenal cortex 2
Cort (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 36 98.72 Very High Very High Very High
isoflurane 5 98.40 Very High Very High Very High
medulla 24 96.72 Very High Very High Very High
antagonist 68 96.32 Very High Very High Very High
anesthesia 1 84.04 Quite High
orphanin 4 75.00 Quite High
Hyperalgesia 4 67.56 Quite High
Serotonin 4 48.68 Quite Low
Eae 4 35.92 Quite Low
depression 32 35.00 Quite Low
Disease Link Frequency Relevance Heat
Stress 323 99.98 Very High Very High Very High
Targeted Disruption 240 98.56 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 8 94.44 High High
Affective Disorder 8 86.04 High High
Hypersensitivity 12 75.92 Quite High
Hyperalgesia 4 67.56 Quite High
Aggression 68 59.24 Quite High
Depression 40 54.04 Quite High
Anxiety Disorder 32 53.44 Quite High
Sprains And Strains 48 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that N/OFQ does not elevate circulating CORT levels; however the injection process itself results in increased CORT secretion.
Positive_regulation (increased) of Localization (secretion) of CORT
1) Confidence 0.60 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19457551 Disease Relevance 0.15 Pain Relevance 0.45
This agonist was the first to show efficacy at nanomolar concentrations and stimulate the release of ACTH/CORT without exhibiting vascular or renal activity (Derick et al. 2002).
Positive_regulation (stimulate) of Localization (release) of CORT associated with agonist
2) Confidence 0.29 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.45 Pain Relevance 0.24
Our studies in Avpr1b KO mice (Lolait et al. 2007a,b; Stewart et al. 2008a,b) and similar studies on acute stress in Brattleboro rats (Domokos et al. 2008; Zelena et al. 2009) both often note a disparity between stress-induced ACTH versus CORT release in Avp/Avpr1b-deficient animals.
Positive_regulation (induced) of Localization (release) of CORT associated with stress and targeted disruption
3) Confidence 0.29 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.93 Pain Relevance 0
The studies in Avpr1b KO mice and Brattleboro rats highlight the discrepancy between Avp/Avpr1b-mediated ACTH and CORT secretion during acute and repeated stress—this may have implications on the potential use of Avpr1b antagonists to ameliorate symptoms of HPA axis hyperactivity in stress-related disorders.


Positive_regulation (mediated) of Localization (secretion) of CORT associated with stress, targeted disruption, antagonist and attention deficit hyperactivity disorder
4) Confidence 0.18 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.84 Pain Relevance 0.05
Discrepancies between plasma stress hormone levels appear stressor specific suggesting that a particular stressor may possess specific characteristics that could activate a number of pathways to promote CORT release, e.g. via direct splanchnic or other neural innervation of the adrenal cortex or medulla (Ehrhart-Bornstein et al. 1998).
Positive_regulation (promote) of Localization (release) of CORT in adrenal cortex associated with stress and medulla
5) Confidence 0.17 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.72 Pain Relevance 0.05

General Comments

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