INT160330

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cort)
Anatomy Link Frequency
plasma 2
Cort (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 5 95.76 Very High Very High Very High
anesthesia 1 86.96 High High
orphanin 4 77.88 Quite High
Catecholamine 3 15.28 Low Low
antagonist 17 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 83 99.84 Very High Very High Very High
Sprains And Strains 12 97.76 Very High Very High Very High
Targeted Disruption 60 73.20 Quite High
Aggression 17 5.00 Very Low Very Low Very Low
Depression 10 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Obesity 3 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Hypoglycemia 3 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that N/OFQ does not elevate circulating CORT levels; however the injection process itself results in increased CORT secretion.
Positive_regulation (circulating) of Gene_expression (levels) of CORT
1) Confidence 0.44 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19457551 Disease Relevance 0.15 Pain Relevance 0.46
Interestingly, C57BL/6ByJ mice display higher levels of plasma CORT as well as increases in stress-related behaviours compared to the Balb/cByJ strain, strengthening support for Avprlb's involvement in mouse stress susceptibility (Anisman et al. 2001).
Positive_regulation (increases) of Gene_expression (levels) of CORT in plasma associated with stress and sprains and strains
2) Confidence 0.18 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.01 Pain Relevance 0

General Comments

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