INT160409

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.95
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
lymph node 2
GCT 1
T cell 1
mast cell 1
Cxcl10 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 135 100.00 Very High Very High Very High
cytokine 90 100.00 Very High Very High Very High
rheumatoid arthritis 204 99.08 Very High Very High Very High
Osteoarthritis 100 97.80 Very High Very High Very High
fibrosis 39 96.48 Very High Very High Very High
Inflammation 185 95.16 Very High Very High Very High
interstitial cystitis 205 92.32 High High
Morphine 6 91.92 High High
antagonist 1 87.60 High High
opioid receptor 1 87.16 High High
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 102 99.46 Very High Very High Very High
Cystitis 350 99.32 Very High Very High Very High
Rheumatoid Arthritis 204 99.08 Very High Very High Very High
Cancer 17 98.52 Very High Very High Very High
Necrosis 12 98.28 Very High Very High Very High
Osteoarthritis 100 97.80 Very High Very High Very High
Fibrosis 37 96.48 Very High Very High Very High
INFLAMMATION 182 95.16 Very High Very High Very High
Interstitial Cystitis 205 92.32 High High
Disease 108 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of CXCL10 blockade to modulate local chemokines as well as Th1 cytokine mRNA expression and to facilitate the decline of serum levels of CXCL9 and CXCL10 is an indication of reduced local as well as systemic inflammation.
Transcription (expression) of CXCL10 associated with chemokine, inflammation and cytokine
1) Confidence 0.65 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.81 Pain Relevance 0.42
We demonstrate that CXCR3 as well as CXCL9, CXCL10 and CXCL11 mRNA were significantly expressed by urinary bladder lymphocytes, while CXCR3 and CXCL9 transcripts were significantly expressed by iliac lymph node leukocytes following CYP treatment.
Transcription (expressed) of CXCL10 in lymph node
2) Confidence 0.50 Published 2008 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC2583981 Disease Relevance 0.55 Pain Relevance 0.35
Urinary bladder histology as well as mucosal (iliac lymph node and urinary bladder) and peripheral (spleen) leukocyte expression of CXCR3, CXCL9, CXCL10, and CXCL11 mRNA transcripts as well as CD4+ T cell, mast cell, and NK/NKT cell numbers were compared among naïve and CYP-treated mice given control or anti-CXCL10 Abs.
Transcription (transcripts) of CXCL10 in T cell
3) Confidence 0.50 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.18 Pain Relevance 0.40
CYP-induced cystitis in mice led to substantial increases in the expression of CXCL10, CXCL11, and CXCR3 mRNA by urinary bladder leukocytes as well as modest increases in the expression of CXCL9 and CXCR3 transcripts by iliac lymph node lymphocytes than compared to normal, untreated mice (Figure 3A).
Transcription (expression) of CXCL10 in lymph node associated with cystitis
4) Confidence 0.50 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.70 Pain Relevance 0.10
CXCL9 mRNA was detected after 29 cycles with the primers 5'-GGA GTG CAA GGA ACC CCA GTA-3' and 5'-CTT TTG GCT GAC CTG TTT CTC-3', and CXCL10 mRNA was amplified using 26 cycles with the primers 5'-ATT TGC TGC CTT ATC TTT CTG-3' and 5'-GAC ATC TCT TCT CAC CCT TCT-3', at annealing temperatures of 52°C and 55°C, respectively.
Transcription (detected) of CXCL10 in GCT
5) Confidence 0.41 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0 Pain Relevance 0
Concomitantly, significantly increased mRNA levels of CXCL9 and CXCL10 were also detected in RA synovial tissue.
Transcription (levels) of CXCL10 associated with rheumatoid arthritis
6) Confidence 0.41 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.29 Pain Relevance 0.72
In the present study, we found that RSV reduces V2O5-induced mRNA levels of type I IFNs, CXCL9 and CXCL10.
Transcription (levels) of CXCL10 associated with respiratory syncytial virus
7) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.28 Pain Relevance 0.31
Urinary bladder histology as well as mucosal (iliac lymph node and urinary bladder) and peripheral (spleen) leukocyte expression of CXCR3, CXCL9, CXCL10, and CXCL11 mRNA transcripts as well as CD4+ T cell, mast cell, and NK/NKT cell numbers were compared among naïve and CYP-treated mice given control or anti-CXCL10 Abs.
Transcription (transcripts) of CXCL10 in mast cell
8) Confidence 0.17 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.18 Pain Relevance 0.40
In addition, the mRNA expression of inducible nitric oxide synthase (iNOS), CD40 ligand, Interferon-gamma-inducible protein 10 (IP-10), and the proinflammatory cytokines tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1beta, and IL-6, which were elevated with Tat alone, were dramatically enhanced with Tat in the presence of morphine.
Transcription (expression) of IP-10 associated with necrosis, cancer, morphine and cytokine
9) Confidence 0.14 Published 2009 Journal J. Neurovirol. Section Abstract Doc Link 19462331 Disease Relevance 0.95 Pain Relevance 0.84

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